Developmental Research program

发展研究计划（DRP）旨在提供资金， 转化研究，重点是脑肿瘤。将高度优先考虑将产生 旨在降低脑肿瘤发病率或死亡率或改善脑肿瘤的临床相关假设 脑肿瘤患者的生活质量。每年至少提出一次关于创新翻译大脑的建议 肿瘤研究将在德克萨斯医学中心的所有机构中征集。预计各国 有些申请人在准备成功的研究计划方面缺乏丰富的经验; 因此，DRP的联合主任将帮助研究人员制定具体的目标和研究计划， 翻译性质的，具有现实和适当的预算。因此，除了开发有前途的 作为SPORE计划的研究项目，DRP也将是一项重要的教育活动， 促进脑癌创新转化研究概念的启动和发展。 SPORE执行委员会将使用以下方法筛选合适的SPORE资格提案： 客观标准。然后，选定的提案将由成员进行科学审查和优先排序 研究项目的最终选择将由 在这些审查的基础上。资助期为两年，并将拨款用于 第二年在对获奖者的书面进度报告进行满意审查后进行。额外 如果认为增加一年的工作将导致独立的同行审查， 资助和/或导致脑肿瘤的诊断或治疗的显着增强;对此的请求 额外的资金将由SPORE执行委员会和外部机构仔细审查。 咨询委员会。作为我们在德克萨斯大学扩大脑肿瘤研究的持续努力的一部分， M. D.安德森癌症中心和预期的这一孢子应用，发展研究 四个项目被认为是最有潜力的，并符合 这里包括了SPORE的翻译重点，代表了将被考虑资助的重点 开始在第一年的SPORE计划。这些项目说明了对以下方面的兴趣的广度和深度： 脑肿瘤转化研究

The Developmental Research Program (DRP) is designed to provide funding to initiate promising translational studies with a focus on brain tumors. High priority will be given to projects that will generate clinically-relevant hypotheses aimed at reducing the morbidity or mortality of brain tumors or improving the quality of life of patients with brain tumors. At least annually, proposals for innovative translational brain tumor research will be solicited throughout all institutions in the Texas Medical Center. It is anticipated that some applicants will be without extensive experience in preparing successful research proposals; therefore, the DRP Co-Directors will help investigators formulate specific aims and research plans that are translational in nature, with realistic and appropriate budgets. Thus, in addition to developing promising research projects for the SPORE program, the DRP will also be a major educational activity that will further enhance the initiation and development of innovative translational research concepts in brain cancer. The SPORE Executive Committee will screen proposals for appropriate SPORE qualifications using objective criteria. The selected proposals will then undergo scientific review and prioritization by members of the SPORE External Advisory Board; final selection of the research projects to be funded will be made on the basis of these reviews. A two-year funding period will be allowed, with allocation of funds for the second year to be made after satisfactory review of a written progress report from the awardee. Additional funding may be granted, if it is felt that an additional year of work will lead to independent peer-reviewed funding and/or lead to significant enhancement in diagnosis or treatment of brain tumors; requests for this additional funding will be very carefully reviewed by the SPORE Executive Committee and External Advisory Board. As part of our continuing efforts to expand brain tumor research at The University of Texas M. D. Anderson Cancer Center and in anticipation of this SPORE application, developmental research projects were solicited; the four projects considered to be of highest potential and consistent with the translational focus of the SPORE are included here and represent those that will be considered for funding to begin in Year 1 of the SPORE program. These projects illustrate the breadth and depth of interest in brain tumor translational research at our institution.