Molecular determinants of susceptibility and progression in breast cancer

乳腺癌易感性和进展的分子决定因素

• 批准号: nhmrc : 1017028
• 负责人: Prof Georgia Chenevix-Trench
• 金额: $ 400.52万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Program Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-determinants-susceptibility-breast-cancer/109819
• 关键词: Molecular; determinants; susceptibility; progression; breast

Breast cancer is heterogeneous, making management a challenge. High-grade cancers including the ‘basal’ type are aggressive, often found in young women and have a propensity for distant spread. They are also associated with a BRCA1 gene mutation. We will study mechanisms that predispose some women to develop breast cancer, the process that allows cancers to grow at distant sites such as the brain and lungs, and how DNA repair proteins are implicated. This will allow development of new diagnostic tools and treatments.

乳腺癌是异质性的，这使得管理成为一个挑战。包括“基底”型在内的高级别癌症具有侵袭性，通常在年轻女性中发现，并有向远处扩散的倾向。它们还与BRCA1基因突变有关。我们将研究使一些女性易患乳腺癌的机制，允许癌症在大脑和肺部等远处生长的过程，以及DNA修复蛋白是如何牵涉其中的。这将允许开发新的诊断工具和治疗方法。