Molecular diagnosis and therapy of autoimmune disease using translational and reverse translational approaches

使用平移和反平移方法进行自身免疫性疾病的分子诊断和治疗

• 批准号: nhmrc : 1196972
• 金额: $ 233.14万
• 依托单位国家: 澳大利亚
• 项目类别: Investigator Grants
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-diagnosis-therapy-translational-approaches/1779225
• 关键词: Molecular; diagnosis; therapy; autoimmune; disease

We plan to translate our recent discoveries on human gene variants and molecules produced by immune cells (follicular T cells) into effective therapies for autoimmune diseases. This will involve understanding the mechanisms by which the genes and molecules regulate immune tolerance, stratifying patients with autoimmune disease using newly identified biomarkers, trialling existing biologicals according to affected molecular pathway, and taking novel targets through to commercialisation.

我们计划将我们最近对人类基因变异和免疫细胞（滤泡T细胞）产生的分子的发现转化为自身免疫性疾病的有效疗法。这将涉及了解基因和分子调节免疫耐受的机制，使用新鉴定的生物标志物对自身免疫性疾病患者进行分层，根据受影响的分子途径试验现有生物制剂，并将新靶点用于商业化。