Molecular determinants of subcellular localisation and function of the transmembrane 4 superfamily protein, PETA-3

跨膜 4 超家族蛋白 PETA-3 的亚细胞定位和功能的分子决定因素

• 批准号: nhmrc : 104856
• 负责人: Prof Leonie Ashman
• 金额: $ 21.53万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2000
• 资助国家: 澳大利亚
• 起止时间: 2000-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-determinants-subcellular-peta-3/81364
• 关键词: Molecular; determinants; subcellular; localisation; function

Several years ago we identified the cell membrane protein PETA-3-CD151 based on its ability to cause activation of blood platelets, suggesting a role in thrombosis. More recently we found that the protein is present in a variety of tissues, although its distribution in those tissues is often restricted. It is abundant in a variety of cancer cells, and is present on tissue mast cells that mediate allergic reactions. PETA-3-CD151 forms complexes with molecules (integrins) that are associated with cell adhesion and migration, and antibodies to this protein inhibit cell movement. Thus PETA-3-CD151 appears to be involved in cellular interactions that are critical for normal tissue development and function, and may be involved in several disease processes including cancer invasion and metastasis. The molecular basis of PETA-3-CD151 function is not understood and is the focus of this application.

几年前，我们根据细胞膜蛋白 PETA-3-CD151 引起血小板活化的能力，发现了它在血栓形成中的作用。最近我们发现该蛋白质存在于多种组织中，尽管它在这些组织中的分布通常受到限制。它在多种癌细胞中含量丰富，并且存在于介导过敏反应的组织肥大细胞上。 PETA-3-CD151 与与细胞粘附和迁移相关的分​​子（整合素）形成复合物，并且该蛋白质的抗体会抑制细胞运动。因此，PETA-3-CD151似乎参与了对正常组织发育和功能至关重要的细胞相互作用，并且可能参与了包括癌症侵袭和转移在内的多种疾病过程。 PETA-3-CD151 功能的分子基础尚不清楚，但这是本申请的重点。