EFFECTS OF A DIETARY SUPPLEMENT ON NON-SMALL CELL LUNG CANCER PATIENTS

膳食补充剂对非小细胞肺癌患者的影响

• 批准号: 7953714
• 负责人: HENRY S SACKS
• 金额: $ 0.12万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7953714
• 关键词: Antiviral Agents; Botanicals; Cancer Etiology; Cancer Patient; Cause of Death; Cessation of life; Chemotherapy-Oncologic Procedure; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Control Groups; Data; Double-Blind Method; Funding; Grant; Herb; Immune; Ingestion; Institution; Living Wills; Meta-Analysis; National Cancer Institute; Non-Small-Cell Lung Carcinoma; North America; Paper; Patients; Placebo Control; Published Comment; Quality of life; Radiation therapy; Randomized; Randomized Clinical Trials; Research; Research Design; Research Personnel; Resources; Source; Staging; Supportive care; Time; Toxic effect; United States National Institutes of Health; Unresectable; Western Europe; chemotherapy; conventional therapy; dietary supplements; effective therapy; lung Carcinoma; response; tumor; web page

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Carcinoma of the lung is the leading cause of cancer related deaths in North America. Non-small Cell Lung Cancer (NSCLC) causes the death of more than 400,000 patients annually in the US and Western Europe. The benefit of conventional therapies, such as chemotherapy and radiotherapy, for unresectable stage IIIB and IV NSCLC patients is marginal; the generally accepted median survival time (MST) of stage IV patients has remained 4-6 months in the "Supportive Care" group and 6-9 months in the treatment group; the one-year survival is about 20%. National Cancer Institute (NCI) quoted in its Web page a meta-analysis of 52 randomized clinical trials that showed an absolute survival benefit of 4% at 2 years with chemotherapy and/or radiotherapy. A recent paper and an Editorial comment of New Engl J Med concluded that 4 widely used chemotherapy regimens offer only marginal benefits with severe toxicities for advanced NSCLC patients and "It is time to move on from chemotherapy. Because of the poor overall results, NCI concludes that More Effective Treatments for NSCLC Are Urgently Needed. SV is a dietary supplement consisting of selected botanicals and herbs chosen for their scientifically documented immune-potentiating, anticancer, or antiviral activity. Preliminary data have shown that daily ingestion of SV can prolong the median survival time 3-fold over the control group of advanced non-small cell lung cancer (NSCLC) patients. This is a randomized, placebo-controlled, double-blind study designed to determine if adding a dietary supplement, (SV) to a standard chemotherapy regimen in patients with Stage IIIB/IV NSCLC will prolong survival. Information about the effects of the addition of SV on tumor response, toxicities and quality of life will also be collected and analyzed.

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