ASSESSMENT OF AGE-RELATED DIFFERENCES IN IN-VITRO CHOLINESTERASE INHIBITION I

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的目的是研究年轻健康成年人和老年健康成年人对一种名为胆碱酯酶抑制剂的药物的敏感性，如普利司替明(Mestinon)、多奈哌齐(Aricept)和加兰他明(Razadyne)。 其中一些药物用于改善阿尔茨海默病患者的记忆功能和行为。其他研究的结果表明，一些人可能比其他人对这些药物的影响更敏感；这项研究将确定年轻人是否可能比老年人对这些影响更敏感。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research is to study the sensitivity of young healthy adults and older healthy adults to a type of drug called cholinesterase inhibitors, such as pryridostigmine (Mestinon ), donepezil (Aricept ) and galantamine (Razadyne ). Some of these drugs are used to improve the memory function and behavior of patients with Alzheimer's Disease. Results from other studies suggest that some people may be more sensitive to the effects of these drugs than others; this research will be to determine if young adults may be more sensitive to the effects than older adults.