ETHNIC DIFFERENCES IN ACUTE PAIN AND ANALGESIC RESPONSE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究将使用常见的急性临床疼痛模型来识别和表征导致疼痛感知和镇痛种族差异的社会心理、生理和遗传因素。 目的1将确定种族群体的感知和生理反应的急性术后疼痛，并检查这些是如何与遗传，术前心理和社会心理因素。 目的2将确定阿片类镇痛和副作用的种族差异，并将检查遗传，药代动力学，药效学和心理社会因素，解释镇痛反应的组间差异。 本研究将纳入300名年龄范围为18岁的少数民族和白色患者，他们接受了第三磨牙拔除术。 将评估术前实验性疼痛反应和心理社会指标，并监测术后疼痛水平沿着药代动力学;以及对阿片类芬太尼的药效学反应。 还将评估术后疼痛以及术后即刻、术后数小时和术后3天内镇痛反应的组间差异。 本研究的长期目标是开发一个程序性的研究路线，旨在阐明生物心理社会的贡献，种族差异的疼痛，并最终从事转化研究，以减少健康差异的临床疼痛，通过开发干预措施，旨在提高个人的生活质量与疼痛。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will use a common acute clinical pain model to identify and characterize psychosocial, physiological and genetic factors that contribute to ethnic group differences in pain perception and analgesia. Aim 1 will determine ethnic group differences in perceptual and physiological responses to acute post-operative pain and to examine how those are related to genetic, pre-operative psychophysical and psychosocial factors. Aim 2 will determine ethnic differences in opioid analgesia and side effects and will examine genetic, pharmacokinetic, pharmacodynamic, and psychosocial factors that explain group differences in analgesic responses. 300 minority and white patients age range 18-who undergo third molar extraction will be included in this study. Preoperative experimental pain responses and psychosocial measures will be assessed and postoperative pain levels along with pharmacokinetic; and pharmacodynamic responses to the opioid fentanyl will be monitored. Group differences in post-operative pain as well as analgesic responses immediately and for several hours post-operatively and up to 3 days post-procedure will also be assessed. The long-term goal of this study is to develop a programmatic line of research designed to elucidate biopsychosocial contributions to ethnic differences in pain and to eventually engage in translational research to reduce health disparities in clinical pain through the development of interventions designed to enhance the quality of life of individuals with pain.