RELATIONSHIP BETWEEN PANCREATIC IRON (R2*) AND PANCREATIC FUNCT IN THALASSEMIA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本实验的目的是确定重症地中海贫血患者的胰铁和/或肝铁是否可以预测胰岛素抵抗和胰岛细胞功能受损。为了达到这些目的，这项实验将要求患者接受MRI肝脏和胰腺铁评估(或使用他们临床扫描的值)，并参加口服葡萄糖耐量测试或单一空腹血糖评估。其目标是提高铁负荷过高患者对糖尿病的临床前认识。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this experiment is to determine whether pancreatic iron, liver iron, or both predict insulin resistance and impaired islet cell function in thalassemia major patients. To address these aims, this experiment will ask patients to undergo MRI liver and pancreatic iron assessment (or use values from their clinical scans) and to participate in either an oral glucose tolerance test or single fasting glucose assessment. The goal is to improve preclinical recognition of diabetes in iron overloaded patients.