RELATIONSHIP BETWEEN PANCREATIC IRON (R2*) AND PANCREATIC FUNCT IN THALASSEMIA

地中海贫血患者胰腺铁 (R2*) 与胰腺功能之间的关系

• 批准号: 7982167
• 负责人: JOHN C WOOD
• 金额: $ 3.01万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7982167
• 关键词: Address; Cell physiology; Clinical; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Cooley' s anemia; Diabetes Mellitus; Funding; Goals; Grant; Institution; Insulin Resistance; Iron; Iron Overload; Islet Cell; Liver; Magnetic Resonance Imaging; OGTT; Pancreas; Patients; Research; Research Personnel; Resources; Scanning; Source; Thalassemia; United States National Institutes of Health; fasting glucose; improved; pre-clinical; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this experiment is to determine whether pancreatic iron, liver iron, or both predict insulin resistance and impaired islet cell function in thalassemia major patients. To address these aims, this experiment will ask patients to undergo MRI liver and pancreatic iron assessment (or use values from their clinical scans) and to participate in either an oral glucose tolerance test or single fasting glucose assessment. The goal is to improve preclinical recognition of diabetes in iron overloaded patients.

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本实验的目的是确定是否胰腺铁，肝铁，或两者预测胰岛素抵抗和受损的胰岛细胞功能的地中海贫血患者。为了实现这些目标，本实验将要求患者接受MRI肝脏和胰腺铁评估（或使用其临床扫描的值），并参加口服葡萄糖耐量试验或单次空腹血糖评估。 其目标是提高铁超载患者对糖尿病的临床前识别。