CLINICAL TRIAL: HEREDITARY CANCER RISK FACTORS AND OUTCOME IN BREAST CANCER PATI

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 研究中心，而研究中心不一定是研究者所在的机构。 本研究的目的是调查可能导致癌症患者和/或其亲属发生特定癌症的因素。 了解癌症发展的主要进展领域之一是遗传学。实验室研究表明，在一些人中，癌症的发生，至少部分是由于遗传的基因模式。基因存在于身体的每个细胞中，包含决定身体构成的遗传信息。在基因中发现的遗传信息通常包含小的变化或改变。有时这些变化不会引起任何问题;其他时候这些变化更严重，可能会干扰基因（或基因）的正常工作。现在有技术可以分析血液和储存的组织样本中的基因，以发现可能与癌症发展有关的改变。由于患者和/或其亲属的癌症诊断，本研究着眼于患者/亲属的血液和/或组织样本，以寻找可能使患者/亲属更有可能患癌症的遗传变化。在他们的许可下，也可以从某些其他家庭成员那里收集标本，如果他们的信息有助于解释家庭中的癌症模式。这项研究还将试图了解癌症的其他可能原因，特别是那些可能与遗传因素相互作用的原因。例如环境或饮食接触。随着研究这些其他可能的癌症原因的技术的发展，这种因果关系可能会被调查。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research study is to investigate factors that may contribute to the development of specific cancers in cancer patients and/or their relatives. One of the major areas of progress in understanding cancer development has been in genetics. Laboratory research has shown that in some people cancer occurs, at least in part, due to an inherited pattern of genes. Genes are in every cell of the body and contain the hereditary information that determines physical makeup. The hereditary information found in genes often contains small changes or alterations. Sometimes these changes do not cause any problems; other times the changes are more serious and can interfere with how a gene (or genes) usually work. Techniques are now available that allow analysis of genes from blood and stored tissue samples for alterations that may be associated with cancer development. Because of the patient's and/or their relative's cancer diagnosis, this study looks at blood and/or tissue samples from the patient/relative for possible genetic changes that may have made the patient/relative more likely to develop cancer. With their permission, specimens may also be collected from certain other family members, if information from them could help to explain a pattern of cancer in the family. This study also will attempt to understand other possible causes of cancer; particularly those that might interact with inherited factors. Examples would be environmental or dietary exposures. As techniques become available to study these other possible causes of cancer, such causal relationships may be investigated.