CLINICAL TRIAL: HEREDITARY CANCER RISK FACTORS AND OUTCOME IN BREAST CANCER PATI

临床试验：乳腺癌 PATI 的遗传性癌症风险因素和结果

• 批准号: 7982053
• 负责人: JEFFREY N WEITZEL
• 金额: $ 28.29万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7982053
• 关键词: Area; Authorization documentation; Blood; Cancer Etiology; Cancer Patient; Clinical Research; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Development; Family; Family member; Funding; Genes; Genetic; Grant; Hereditary Malignant Neoplasm; Inherited; Institution; Laboratory Research; Malignant Neoplasms; Mutation; Outcome; Patients; Pattern; Relative (related person); Research; Research Personnel; Resources; Risk Factors; Source; Specimen; Techniques; Time; Tissue Sample; United States National Institutes of Health; Work; cancer diagnosis; cancer risk; genetic risk factor; malignant breast neoplasm; neuronal cell body; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research study is to investigate factors that may contribute to the development of specific cancers in cancer patients and/or their relatives. One of the major areas of progress in understanding cancer development has been in genetics. Laboratory research has shown that in some people cancer occurs, at least in part, due to an inherited pattern of genes. Genes are in every cell of the body and contain the hereditary information that determines physical makeup. The hereditary information found in genes often contains small changes or alterations. Sometimes these changes do not cause any problems; other times the changes are more serious and can interfere with how a gene (or genes) usually work. Techniques are now available that allow analysis of genes from blood and stored tissue samples for alterations that may be associated with cancer development. Because of the patient's and/or their relative's cancer diagnosis, this study looks at blood and/or tissue samples from the patient/relative for possible genetic changes that may have made the patient/relative more likely to develop cancer. With their permission, specimens may also be collected from certain other family members, if information from them could help to explain a pattern of cancer in the family. This study also will attempt to understand other possible causes of cancer; particularly those that might interact with inherited factors. Examples would be environmental or dietary exposures. As techniques become available to study these other possible causes of cancer, such causal relationships may be investigated.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的目的是调查可能导致癌症患者和/或其亲属发生特定癌症的因素。在理解癌症发展方面取得进展的主要领域之一是遗传学。实验室研究表明，在一些人中，癌症的发生至少部分是由于基因的遗传模式。基因存在于人体的每个细胞中，包含决定身体构成的遗传信息。在基因中发现的遗传信息通常包含微小的变化或改变。有时这些变化不会造成任何问题；有时这些变化更严重，可能会干扰一个(或多个)基因通常的工作方式。现在可以使用的技术可以分析血液和存储的组织样本中的基因，以确定可能与癌症发展相关的变化。由于患者和/或其亲属的癌症诊断，这项研究着眼于患者/亲属的血液和/或组织样本，以寻找可能使患者/亲属更有可能患癌症的基因变化。在他们的许可下，也可以从某些其他家庭成员那里收集样本，如果他们的信息可以帮助解释家庭中的癌症模式。这项研究还将试图了解癌症的其他可能原因；特别是那些可能与遗传因素相互作用的原因。环境或饮食暴露就是一个例子。随着研究这些其他可能的癌症原因的技术变得可行，这种因果关系可能会被调查。