THE EFFECT OF AROMATASE INHIBITION ON THE COGNITIVE FUNCTION OF OLDER PATIENTS W

芳香酶抑制对老年患者认知功能的影响

• 批准号: 7982085
• 负责人: ARTI HURRIA
• 金额: $ 5.8万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7982085
• 关键词: Adjuvant; Advanced Glycosylation End Products; Age; Aromatase Inhibition; Aromatase Inhibitors; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Control Groups; Data; Disease-Free Survival; Frequencies; Funding; Goals; Grant; Hormone Receptor; Impaired cognition; Institution; Memory; Patients; Pilot Projects; Postmenopause; Research; Research Personnel; Resources; Risk; Secondary to; Source; Tamoxifen; United States National Institutes of Health; Woman; cognitive function; malignant breast neoplasm; neuroimaging; older patient

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The aromatase inhibitors are being used with increasing frequency for the adjuvant treatment of postmenopausal hormone receptor positive breast cancer secondary to the emerging data demonstrating a benefit in disease free survival among patients receiving an aromatase inhibitor in comparison to tamoxifen. 1-4 The potential impact of the aromatase inhibitors on cognitive function has not been elucidated. The goal of this pilot study is to explore the relationship between treatment with an aromatase inhibitor and objective memory, subjective memory, and functional neuroimaging correlates in postmenopausal women with breast cancer (N=25) in comparison to an age-matched healthy control group not receiving aromatase inhibitor therapy (N=25). In addition, we will explore the relationship between the level of advanced glycation endproducts and baseline cognitive function, as well as the risk of further cognitive decline on aromatase inhibitor therapy.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 芳香酶抑制剂被越来越频繁地用于绝经后激素受体阳性乳腺癌的辅助治疗，继发于新出现的数据，这些数据表明与他莫昔芬相比，接受芳香酶抑制剂的患者的无病生存期有所改善。1-4芳香酶抑制剂对认知功能的潜在影响尚未阐明。本初步研究的目的是探索芳香化酶抑制剂治疗与客观记忆、主观记忆和功能性神经影像学相关性之间的关系，并与未接受芳香化酶抑制剂治疗的年龄匹配的健康对照组（N = 25）进行比较。此外，我们还将探讨晚期糖基化终产物水平与基线认知功能之间的关系，以及芳香化酶抑制剂治疗后认知功能进一步下降的风险。