Developing and Improving Institutional Animal Resources (G20)

描述（由申请人提供）：埃默里大学致力于成为发现和研究领域的领先机构。埃默里大学的研究蓬勃发展，因为我们在获得NIH资助的大学中排名上升了10位（从1996年的第32位）到2005年的第22位。研究事业的这种增长主要是通过小灵通资助的研究和使用动物模型的小鼠。鉴于这种动态，提高生产力和留住常驻科学家以及招募顶级生物医学研究人员的关键是研究资源，包括对大量低成本小鼠的支持。埃默里大学在过去的6年里建造或翻新了总共81,829平方英尺的动物研究设施，总容量增加了76%，达到146,424平方英尺，总成本为24,788,797美元。为了补充这些资源，我们寻求获得15个啮齿类动物通风笼系统，每个系统可容纳140个笼子（840只老鼠），并自动供水，以满足这种扩张势头和由此产生的对更多老鼠笼的相关需求。购买这些笼子将使埃默里大学的研究人员以更低的成本获得更高密度的老鼠住房，并对NIH拨款的申请有重大好处。这些笼化系统每年将为研究人员节省高达122640美元的成本，并将直接支持158名科学家使用小鼠的工作，其中208项目前资助的小灵通拨款为4060万美元，34项小灵通拨款为700万美元。

DESCRIPTION (provided by applicant): Emory University seeks to advance as a leading institution in discovery and research. Research at Emory has flourished as our institutional rank among universities with NIH awarded grants has increased 10 places (from 32nd) since 1996 to 22nd in 2005. This growth in the research enterprise has been primarily through PHS sponsored research and, where animal models are used, with mice. Given this dynamic, the key to the productivity and retention of our resident scientists and recruitment of top tier biomedical investigators are research resources, including support for large numbers of mice at low cost. Emory University has in the past 6 years constructed or renovated a total of 81,829 GSF of animal research facilities increasing overall capacity by 76% to 146,424 GSF and at a total cost of $24,788,797. To compliment these resources, we seek to acquire 15 rodent ventilated caging systems with 140 cage (840 mouse) capacity each and automated water supply to build foremost upon this momentum of expansion and the associated need for more mouse caging that it has created. The purchase of these cages will allow for higher density mouse housing at lower cost for Emory investigators and with significant benefits to the application of NIH grant dollars. These caging systems will enable up to $122,640 annual cost savings passed on to investigators and will directly support the work of 158 scientists using mice with $40.6M direct costs in 208 currently funded PHS grants and with 34 PHS grants for $7M pending.