Assessment of Potential Cocaine Pharmacotherapies in Monkeys

拟议研究的主要目标是对可能有助于治疗可卡因滥用和依赖的测试化合物提供敏感、有效和标准化的行为评估。研究将通过在非人类灵长类动物身上建立良好的方案来进行。如果NIDA提出要求，将制定新的程序。将按照NIDA的规定，在整个合同期内仔细记录在任务1和任务2下测试的所有化合物，并按要求提交规范报告。NIDA提供的测试化合物将测试它们对抗可卡因的歧视性刺激效应的能力。

The primary objective of the proposed studies is to provide sensitive, efficient and standardized behavioral evaluations of test compounds that may be useful for the treatment of cocaine abuse and dependence. Studies will be carried out by means of well-established protocols in nonhuman primates. New procedures will be developed if requested by NIDA. Careful records of all compounds tested under both Tasks 1 and 2 will be maintained throughout the contract period as specified by NIDA, and regualr reports will be filed as required. Test compounds provided by NIDA will be tested for their ability to antagonize the discriminative stimulus effects of cocaine.