Assessment of Potential Cocaine Pharmacotherapies in Monkeys

猴子潜在可卡因药物治疗的评估

• 批准号: 7678845
• 金额: $ 73.43万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-07 至 2013-07-06
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7678845
• 关键词: Assessment; Potential; Cocaine; Pharmacotherapies; Monkeys

The primary objective of the proposed studies is to provide sensitive, efficient and standardized behavioral evaluations of test compounds that may be useful for the treatment of cocaine abuse and dependence. Studies will be carried out by means of well-established protocols in nonhuman primates. New procedures will be developed if requested by NIDA. Careful records of all compounds tested under both Tasks 1 and 2 will be maintained throughout the contract period as specified by NIDA, and regualr reports will be filed as required. Test compounds provided by NIDA will be tested for their ability to antagonize the discriminative stimulus effects of cocaine.

拟议研究的主要目的是提供敏感、有效和标准化的测试化合物的行为评价，这可能有助于治疗可卡因滥用和依赖。将通过在非人灵长类动物中完善的方案进行研究。如果NIDA提出要求，将制定新的程序。按照NIDA的规定，在整个合同期内，应仔细记录任务1和任务2下测试的所有化合物，并按要求提交定期报告。将测试由NIDA提供的测试化合物拮抗可卡因的辨别刺激作用的能力。