Epidemiology of Glycemia Inflammation & Cognition

血糖炎症的流行病学

• 批准号: 7585919
• 负责人: Rachel A Whitmer
• 金额: $ 0.11万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7585919
• 关键词: Alzheimer' s Disease; Area; Award; Cognition; Cognitive; Collaborations; Dementia; Development Plans; Diabetes Mellitus; Disease; Elderly; Endocrinology; Environment; Epidemiology; Episodic memory; Ethnic group; Fasting; Funding; Glean; Glucose; Glycosylated Hemoglobin; Goals; Hemoglobin; Impaired cognition; Inflammation; Inflammatory; Insulin; Insulin Resistance; Interleukin-6; Knowledge; Latino; Learning; Measurement; Measures; Mediating; Mentored Research Scientist Development Award; Mentors; Neurocognitive; Neurology; Non-Insulin-Dependent Diabetes Mellitus; Numbers; Participant; Patients; Performance; Plasminogen Activator; Prospective Studies; Proteins; Range; Research; Research Personnel; Resources; Risk; Risk Factors; Scientist; Series; Short-Term Memory; Structure; Training; Tumor Necrosis Factor-alpha; Vascular Dementia; Woman; career; cognitive function; cohort; glucose tolerance; glycemic control; memory process; middle age; multidisciplinary; non-diabetic; processing speed; programs; skills

This application is for a KOI Mentored Research Scientist Development Award through which the candidate will learn how type 2 diabetes, glucose disorders, arid inflammationcontribute to cognitive decline and dementia. The overall goal of this proposal will be to determine whether levels of glycemia and insulinemia are predictive of cognitive decline across the entire range of glucose tolerance and across different ethnic groups. Furthermore, whether differences in inflammation explain predictive associations between glycemia and cognitive performance will be examined. Within the research plan, this goal will be achieved though conducting three prospective studies. The following are the specific aims: 1). To determine the association of measures of glycemia and insulinemia with cognitive functioning. . 2). To determine if the association of type 2 diabetes, markers of glycemia and insulinemia, with cognition is mediated by levels of inflammation including c reactive protein, tumor necrosis factor alpha-1, interleukin-6, and plasminogen activator-1. 3). To determine how longitudinal changes in glycemia and insulinemia are associated with cognitive impairment. 4). To determine how glycated hemoglobin is associated with risk of incident dementia, Alzheimer's disease and vascular dementia in patients with Type 2 diabetes. A multidisciplinary team of established senior investigators, each with a different area of expertise andtraining including diabetes, neurology and epidemiology, has been formed to mentor the candidate on the research and career development plan proposed. The training component of the career plan includes the skills gleaned from the research plan as well as an impressive array of structured activities including formal coursework in diabetes, inflammationand endocrinology, participation in several seminar series on diabetes and dementia, additional collaborations with a biostatistician and geriatrician, regular mentoring interactions; and attendance/presentation at several scientific meetings. The candidatehas proposed three studies which seek to gain new knowledge about glycemic and inflammatory risk factors for cognitive impairment in multiethnic cohorts. The expected results should provide new and clinically useful information regarding the influencesof glycemic control and glucose disorders on neurocognitive functioning. The proposed KOI application includes an excellent research environment including resources specific to the goals of the training plan, an established team of mentors and, an important research question. The support from the Mentored Scientist Career Award will enable the candidate to make the transition to an independent investigator in the area of glycemia and cognition including establishing an extramurally funded research program.

此应用程序是一个KOI指导研究科学家发展奖，通过该候选人 将学习2型糖尿病、葡萄糖紊乱、炎症是如何导致认知能力下降和痴呆的。的 这项提案的总体目标是确定胰岛素水平和胰岛素血症是否是认知功能障碍的预测指标。 在整个葡萄糖耐量范围内和不同种族群体中均出现下降。此外，无论 炎症的差异解释了炎症和认知表现之间的预测性关联， 考察在研究计划中，将通过进行三项前瞻性研究来实现这一目标。的 具体目标如下： 1）。确定认知功能与血糖和胰岛素血症指标的相关性。. 2）。确定2型糖尿病、糖尿病和胰岛素血症的标志物与认知的关联是否是介导的 炎症水平包括c反应蛋白、肿瘤坏死因子α-1、白细胞介素-6和纤溶酶原 激活剂-1。 （3）第三章。确定胰岛素水平和胰岛素血症的纵向变化与认知功能障碍的关系。 4）。为了确定糖化血红蛋白与痴呆、阿尔茨海默病和 2型糖尿病患者的血管性痴呆 一个由资深调查员组成的多学科小组，每个人都有不同的专业知识和培训 包括糖尿病，神经病学和流行病学，已经形成了指导候选人的研究和职业生涯 发展计划提出。职业规划的培训部分包括从研究中收集的技能 计划以及一系列令人印象深刻的结构化活动，包括糖尿病，炎症和 内分泌学，参加了几个关于糖尿病和痴呆症的系列研讨会，与 生物统计学家和老年医学家，定期指导互动;以及出席/介绍几个科学 会议.候选人提出了三项研究，旨在获得关于血糖和 多种族队列中认知障碍的炎症危险因素预期结果应提供新的和 关于血糖控制和葡萄糖紊乱对神经认知功能影响的临床有用信息 功能拟议的KOI应用程序包括一个优秀的研究环境，包括特定的资源， 培训计划的目标，一个既定的导师团队，一个重要的研究问题。的支持 指导科学家职业奖将使候选人能够过渡到一个独立的研究者， 包括建立一个由校外资助的研究项目。