Chemokines and their receptors in the pathogenesis of tuberculosis

描述（由申请人提供）：候选人：Gillian Beamer博士，一名具有兽医解剖病理学委员会资格的执业兽医，正在俄亥俄州州立大学（OSU）完成博士培训课程。K 08 MSCDA将支持她加速向科学独立的过渡。环境：OSU的传染病部门和兽医生物科学部门（VBS）是大型，资金充足的生物医学研究中心，拥有教师，最先进的核心设施和有效培训临床科学家的历史。导师们：乔安妮·特纳博士和拉里·施莱辛格博士是在微生物界面生物学中心（CMIB）和VBS联合任命的教员。两位导师都在结核病研究方面经验丰富，都致力于候选人的成功。培训计划：为期4年的职业发展计划将加速比默博士向科学独立的过渡。在博士学位完成和K 08奖，她将立即有资格申请工作，并为工作人员科学家职位的高度重视的候选人。该计划包括一个短暂的重叠期，用于监督博士学位的完成，然后是研究计划中概述的指导项目。指导将在奖励的前2年内基本上集中;在最后2年，联系将保持在一个较低的水平，以促进科学的发展。建议：肺内肉芽肿的形成是控制结核分枝杆菌生长所必需的。然而，细胞募集形成肉芽肿的机制尚不完全清楚。强大的趋化细胞因子（趋化因子）及其受体可能通过协调T细胞迁移到感染部位，在肉芽肿形成和维持中发挥重要作用。在这个建议中，我们将确定趋化因子的作用，免疫学后果和机制的T细胞募集肉芽肿在体内结核分枝杆菌肺部感染。确定结核分枝杆菌肉芽肿形成的基本标准将进一步加深我们对产生保护性免疫的要求的理解。

DESCRIPTION (provided by applicant): THE CANDIDATE: Dr. Gillian Beamer, a licensed veterinarian with board-eligibility in veterinary anatomic pathology, is completing a PhD training program at The Ohio State University (OSU). This K08 MSCDA will support her accelerated transition to scientific independence. THE ENVIRONMENT: OSU's Division of Infectious Diseases and Department of Veterinary Biosciences (VBS) are large, well funded biomedical research centers with faculty, state-of-the-art core facilities and a history of effectively training clinician scientists. THE MENTORS: Dr. Joanne Turner and Dr. Larry Schlesinger are faculty members with joint appointments in the Center for Microbial Interface Biology (CMIB) and VBS. Both mentors are highly experienced in tuberculosis research and both are dedicated to the success of the candidate. THE TRAINING PLAN: The 4-year career development plan will accelerate Dr. Beamer's transition to scientific independence. Upon PhD completion and K08 award, she will be immediately eligible for job application and a highly valued candidate for staff scientist positions. The plan includes a short overlapping period for supervised PhD completion followed by the mentored projects outlined in the research plan. Mentoring will be substantially focused during the first 2 years of the award; in the last 2 years, contact will be maintained at a reduced level to facilitate scientific growth. THE PROPOSAL: Granuloma formation in the lungs is required to control M.tb growth. The mechanisms of cellular recruitment to form granulomas, however, are not fully known. Powerful chemoattractant cytokines (chemokines) and their receptors may play vital roles in granuloma formation and maintenance by orchestrating migration of T cells to sites of infection. In this proposal, we will determine the role of chemokines, immunologic consequences and mechanisms of T cell recruitment to granulomas in response to M.tb lung infection in vivo. Defining essential criteria for M.tb granuloma formation will further our understanding of the requirements for the generation of protective immunity.