ACT 2 PROJ 2 LONGEVITY FOODS AND OBESITY-ASSOCIATED INSULIN RESISTANCE

行动 2 项目 2 长寿食品和肥胖相关的胰岛素抵抗

• 批准号: 7959178
• 负责人: Pratibha V Nerurkar
• 金额: $ 12.36万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7959178
• 关键词: Adipocytes; Adverse effects; American; Asians; Body Weight decreased; CCL4 gene; Cardiovascular Diseases; Chronic Disease; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Consumption; Diabetes Mellitus; Diet; Drug Interactions; Dyslipidemias; Epidemic; Failure; Food; Funding; Goals; Grant; Heart Diseases; In Vitro; Institution; Insulin Resistance; Intake; Intervention; Japanese Population; Link; Longevity; Medical; Melons; Minority; Molecular Target; Momordica charantia; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcomes Research; PPAR gamma; Pharmaceutical Preparations; Population; Research; Research Personnel; Resources; Source; Surgeon; Translating; Treatment Protocols; United States; United States National Institutes of Health; Vegetables; Weight Gain; diabetic; fruits and vegetables; functional food; in vivo; lifestyle factors; prevent; therapeutic development

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Obesity has reached epidemic proportions in the United States and is closely linked to type 2 diabetes and cardiovascular disease (CVD), leading the Surgeon General to issue a call for a national effort not only to identify the causes of obesity, but also to outline effective and culturally appropriate interventions. Efficacies of current therapies for obesity are complicated due to inability to maintain long-term weight loss, while those for type 2 diabetes are prone to drug-drug interactions and various side effects, such as additional weight gain and secondary failure. Interestingly, the occurrence of chronic diseases, such as diabetes and heart disease, among Okinawan Japanese is only one fifth that of Americans. Among the various lifestyle factors are lower calorie intake and high consumption of fruits and vegetables. The long-term goal of this research is to investigate the efficacy of medicinal/functional foods to prevent and/or ameliorate obesity-associated insulin resistance, diabetic dyslipidemia and CVDs, and to identify the underlying mechanisms. This project aims to identify specific molecular targets and delineate the mechanisms involved in ameliorating obesity-associated insulin resistance, using Momordica charantia (bitter melon, BM), an Asian vegetable. The specific aim of the project in year three was to investigate Sirt-PPARgamma-NCoR interactions in adipocytes. We expect to translate the results of the in vitro and in vivo studies to clinical trials among minority populations with obesity and/or type 2 diabetes mellitus. Such studies may have a significant impact on the development of therapeutic regimens that can be incorporated into the daily diet.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 肥胖在美国已达到流行病的程度，并且与 2 型糖尿病和心血管疾病 (CVD) 密切相关，因此美国卫生局局长呼吁全国不仅要努力查明肥胖的原因，还要制定有效且适合文化的干预措施。由于无法维持长期体重减轻，目前治疗肥胖症的疗法的疗效很复杂，而治疗 2 型糖尿病的疗法则容易出现药物间相互作用和各种副作用，例如体重额外增加和继发性失败。有趣的是，冲绳日本人患糖尿病、心脏病等慢性病的比例仅为美国人的五分之一。各种生活方式因素包括较低的热量摄入和大量的水果和蔬菜消耗。这项研究的长期目标是调查药用/功能性食品预防和/或改善肥胖相关的胰岛素抵抗、糖尿病血脂异常和心血管疾病的功效，并确定其潜在机制。该项目旨在利用亚洲蔬菜苦瓜（苦瓜，BM）来确定特定的分子靶点并描述改善肥胖相关胰岛素抵抗的机制。第三年该项目的具体目标是研究脂肪细胞中的 Sirt-PPARgamma-NCoR 相互作用。 我们期望将体外和体内研究的结果转化为针对少数肥胖和/或 2 型糖尿病人群的临床试验。此类研究可能会对可纳入日常饮食的治疗方案的开发产生重大影响。