开发用于治疗神经退行性疾病的 UCH-L1 抑制剂-猫眼课题宝

开发用于治疗神经退行性疾病的 UCH-L1 抑制剂

批准号：

7675299

负责人：

Melissa Rae Landon

金额：

$3.17万

依托单位：

BRANDEIS UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

2008

资助国家：

美国

项目状态：

已结题

起止时间：

2008-02-04 至 2009-09-11

来源：

https://reporter.nih.gov/project-details/7675299

关键词：

Adverse effects Alzheimer&apos s Disease Binding Binding Sites Characteristics Chemicals Computer Simulation Crystallography Data Development Directories Down-Regulation Drug Industry Enzymes Family suidae Frequencies Goals Homology Modeling Huntington Disease Hydrolase Induced Mutation Institutes Lead Learning Ligand Binding Maps Melissa Membrane Proteins Memory Methods Molecular Chaperones Molecular Conformation Mutation Neurodegenerative Disorders Normal Cell Pancreatic Elastase Parkinson Disease Pharmaceutical Preparations Point Mutation Predisposition Prevention Protein Region Proteins Published Directory Roentgen Rays Screening procedure Serine Silicon Dioxide Solvents Structure Synaptic plasticity Techniques Testing Therapeutic Thermolysin Tyrosine Ubiquitin base brain tissue cost enzyme replacement therapy inhibitor/antagonist molecular dynamics mouse model mutant protein structure research study small molecule small molecule libraries virtual

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会议论文

Development of Inhibitors of UCH-L1 for treatment of neurodegenerative disorders

批准号：

7486456
项目类别：
资助金额：

$4.48万
财政年份：

2008
负责人：

Melissa Rae Landon
依托单位：

BRANDEIS UNIVERSITY