IDENTIFICATION OF ORTHOPOXVIRUS-DERIVED CD8+ T CELL EPITOPES MACAQUES

正痘病毒来源的 CD8 T 细胞表位猕猴的鉴定

• 批准号: 7715471
• 负责人: STEPHEN R WALSH
• 金额: $ 12.98万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-05 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7715471
• 关键词: Acquired Immunodeficiency Syndrome; CD8B1 gene; Cells; Computer Retrieval of Information on Scientific Projects Database; Epitopes; Funding; Genome; Grant; Institution; Macaca; Open Reading Frames; Orthopoxvirus; Play; Poxviridae Infections; Research; Research Personnel; Resources; Role; Source; T-Lymphocyte; T-Lymphocyte Epitopes; United States National Institutes of Health; Vaccination; Vaccinia; Vaccinia virus; Viral Proteins; Virus; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Vaccination with vaccinia virus induces a vigorous virus-specific CD8+ T cell response that plays an important role in control of poxvirus infection. However, little is known about the specific viral proteins that are serve as targets of vaccinia-specific CD8+ T cells, and identification of T cell epitopes in a genome that encodes over 200 open reading frames (ORFs) is a particularly challenging task. AIDS related.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 痘苗病毒疫苗接种可诱导强烈的病毒特异性 CD8+ T 细胞反应，在控制痘病毒感染中发挥重要作用。 然而，人们对作为牛痘特异性 CD8+ T 细胞靶标的特定病毒蛋白知之甚少，并且在编码 200 多个开放阅读框 (ORF) 的基因组中鉴定 T 细胞表位是一项特别具有挑战性的任务。 艾滋病相关。