IDENTIFICATION OF ORTHOPOXVIRUS-DERIVED CD8+ T CELL EPITOPES MACAQUES

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Vaccination with vaccinia virus induces a vigorous virus-specific CD8+ T cell response that plays an important role in control of poxvirus infection. However, little is known about the specific viral proteins that are serve as targets of vaccinia-specific CD8+ T cells, and identification of T cell epitopes in a genome that encodes over 200 open reading frames (ORFs) is a particularly challenging task. AIDS related.