PILOT OF GREEN TEA FOR WEIGHT LOSS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 绿色茶提取物是没有处方，并作为膳食补充剂出售。 它没有被批准用于预防或治疗任何疾病，也从未被食品和药物管理局评估用于减肥或治疗肥胖。以前的人类研究表明，绿色茶提取物可能有助于超重的人减肥。绿色茶尚未在肥胖患者中进行研究。这项双盲随机研究的主要目的是评估肥胖受试者服用绿色茶提取物是否比服用安慰剂在18周内减轻更多体重。 研究人员还将研究绿色茶提取物是否会影响身体成分和能量代谢。 他们还将研究绿色茶提取物是否可以改变血清甘油三酯和胆固醇的水平。 这项研究的第二个目的是观察一种名为“儿茶酚-o-甲基转移酶”的基因的个体差异是否与体重减轻有关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Green tea extract is available without a prescription and is sold as a dietary supplement. It is not approved to prevent or cure any disease and has never been evaluated by the Food and Drug Administration for weight loss or the treatment of obesity. Previous research studies in humans indicate that green tea extracts may help overweight people lose weight. Green tea has not been studied in patients who are obese. The main purpose of this double-blinded, randomized study is to evaluate whether taking a green tea extract results in more weight loss over 18 weeks than taking placebos in obese subjects. The investigators will also study whether green tea extract affects body composition and as energy metabolism. They will also study whether green tea extract can change the levels of serum triglycerides and cholesterol. A secondary purpose of the study is to see if individual differences in a gene called "catechol-o-methyl transferase" are related to weight loss.