GLYCEMIC LOAD AND FETAL GROWTH

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a randomized controlled feeding study. Participants, 60 women age 25 years or older with impaired glucose tolerance, will be recruited from the outpatient clinics at BIDMC. After confirming eligibility by an oral glucose tolerance test, subjects will be assigned to either a low glycemic load diet or a conventional diet designed to satisfy all current nutritional recommendations for optimal health during pregnancy. The primary endpoint will be birth weight of the offspring; the process/compliance measure will be unannounced 24-hour dietary recall; secondary endpoints will include maternal weight gain, metabolic syndrome components in the mother, and adiposity and cord blood analysis in the infant.