FIFTY-YEAR MEDALIST

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 这是一项横断面观察性研究，研究对象是被授予乔斯林50年奖章的个人。Joslin的奖章计划旨在表彰那些患有胰岛素依赖型糖尿病25年，50年和75年的人，并颁发特别奖项，以纪念他们对终身糖尿病管理的贡献。 根据之前的兴趣和预期获奖者数量，预计约有400例受试者入组研究。本研究有三个具体目的，第一个目的是记录与糖尿病相关的微血管和大血管并发症（神经病变、肾病、视网膜病变和心血管疾病）的临床证据。第二个具体目标是检查生化因素，这可能有助于理解为什么一些奖牌获得者能够生存而没有并发症。第三个具体目标是在第二个之后，检查与血管损伤的生理途径相关的遗传多态性。数据收集期预计为两年。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a cross-sectional observational study of individuals who have been awarded the Joslin fifty year medal. Joslin's Medal Program recognizes individuals who have lived with insulin-dependent diabetes for 25, 50 and 75 years with special awards to commemorate their dedication to lifelong diabetes management. Approximately 400 subjects are expected to enroll in the study based on previous interest and the number of expected Medalists. There are three specific aims of the study, the first of which is to document the clinical evidence of micro and macrovascular complications associated with diabetes (neuropathy, nephropathy, retinopathy, and cardiovascular disease). The second specific aim is an examination of biochemical factors which may help in understanding why some Medalists have been able to survive without complications. The third specific aim follows on the second, to examine genetic polymorphisms which have been associated with the physiologic pathways of vascular damage. The period of data collection is expected to be two years.