COMPARISON OF CORONARY ARTERY GRAFT PATENCY USING ANGIOGRAPHY AND 64-SLICE CT

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目的：本研究的目的是确定64层多层螺旋CT（MSCT）与冠状动脉造影（CA）相比在评价圣安东尼奥VA医院（AMVAH）CSP 517研究中已入组的无症状患者术后1年冠状动脉旁路移植术（CABG）通畅性方面的准确性。 研究方法：这是一项比较性前瞻性研究，AMVAH患者之前入组了VA合作研究，标题为“心肌血运重建术后的结局：开和关心脏搭桥术”（CSP 517），这些患者已完成CSP 517方案的参与，接受了1年的冠状动脉造影，并且没有MSCT禁忌症。 来自CSP 517研究的不符合排除标准的患者将被邀请参加这项初步研究，主要目的是在一年随访CA后两个月内完成64层MSCT。 临床相关性：本研究将确定与“金标准”CA相比，64层MSCT是否可以以更低的风险和更低的成本为无症状的CABG后患者提供等效的移植物通畅信息。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. OBJECTIVE: The objective of this study is to determine the accuracy of 64-slice Multislice Spiral Computer Tomography (MSCT) when compared to Coronary Angiography (CA) for evaluation of Coronary Artery Bypass Graft (CABG) patency, in asymptomatic patients one year after surgery, already enrolled in the CSP 517 study at the San Antonio VA Hospital (AMVAH). RESEARCH PLAN AND METHODS: This is a comparative, prospective study with AMVAH patients previously enrolled in the VA Cooperative Study entitled "Outcomes Following Myocardial Revascularization: On and Off Cardiopulmonary Bypass" (CSP 517) who have completed their participation in the CSP 517 protocol, have had their one-year coronary angiogram, and do not have a contraindication to MSCT. Patients from the CSP 517 study who do not meet exclusion criteria will be invited to participate in this pilot study with the primary objective of completing a 64-slice MSCT within two months after having the one-year follow-up CA. CLINICAL RELEVANCE: This study will determine if 64-slice MSCT can offer equivalent graft patency information in asymptomatic post-CABG patients when compared to the "gold standard" CA, with less risk and at a lower cost.