COMPARISON OF CORONARY ARTERY GRAFT PATENCY USING ANGIOGRAPHY AND 64-SLICE CT

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. OBJECTIVE: The objective of this study is to determine the accuracy of 64-slice Multislice Spiral Computer Tomography (MSCT) when compared to Coronary Angiography (CA) for evaluation of Coronary Artery Bypass Graft (CABG) patency, in asymptomatic patients one year after surgery, already enrolled in the CSP 517 study at the San Antonio VA Hospital (AMVAH). RESEARCH PLAN AND METHODS: This is a comparative, prospective study with AMVAH patients previously enrolled in the VA Cooperative Study entitled "Outcomes Following Myocardial Revascularization: On and Off Cardiopulmonary Bypass" (CSP 517) who have completed their participation in the CSP 517 protocol, have had their one-year coronary angiogram, and do not have a contraindication to MSCT. Patients from the CSP 517 study who do not meet exclusion criteria will be invited to participate in this pilot study with the primary objective of completing a 64-slice MSCT within two months after having the one-year follow-up CA. CLINICAL RELEVANCE: This study will determine if 64-slice MSCT can offer equivalent graft patency information in asymptomatic post-CABG patients when compared to the "gold standard" CA, with less risk and at a lower cost.