NATRIURETIC PEPTIDE RESPONSE TO SALINE INFUSION

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 心房钠尿肽 (ANP) 和脑钠尿肽 (BNP) 由心脏分泌，以应对心壁应力增加。 超重和肥胖个体的血浆利尿钠肽水平显着低于瘦个体。 我们的研究旨在确定瘦人、胃绕道手术减肥前肥胖者和减肥后肥胖者对盐水输注的利钠肽、回声和代谢反应是否存在差异。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are secreted by the heart in response to increased cardiac wall stress. Overweight and obese individuals have substantially lower plasma natriurietic peptide levels than lean individuals. Our study aims to determine if the natriuretic peptide, echo, and metabolic responses to saline infusion differ between lean individuals, obese individuals before, and obese individuals after weight loss from gastric bypass surgery.