NATRIURETIC PEPTIDE RESPONSE TO SALINE INFUSION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 心房利钠肽(ANP)和脑钠素(BNP)是心脏对心壁压力增加的反应而分泌的。超重和肥胖者的血浆钠尿肽水平显著低于瘦肉者。我们的研究旨在确定胃旁路手术后体重减轻后，瘦人、肥胖者和肥胖者对生理盐水输注的利钠肽、ECHO和代谢反应是否存在差异。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are secreted by the heart in response to increased cardiac wall stress. Overweight and obese individuals have substantially lower plasma natriurietic peptide levels than lean individuals. Our study aims to determine if the natriuretic peptide, echo, and metabolic responses to saline infusion differ between lean individuals, obese individuals before, and obese individuals after weight loss from gastric bypass surgery.