OPEN LABEL CREATINE MONOHYDRATE DOSAGE-ESCALATION STUDY

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There are many proposed mechanisms of motor neuron death in ALS, including mitochondrial dysfunction. Mitochondria play a major role in the metabolic and apoptotic pathways of cells. Creatine has shown to stabilize the mitochondrial activity, which makes it appropriate for evaluation in the treatment of ALS. This study will establish pharmacokinetic data and determine if there are increased brain levels of creatine, at escalating doses.