OPEN LABEL CREATINE MONOHYDRATE DOSAGE-ESCALATION STUDY

开放标签一水肌酸剂量递增研究

• 批准号: 7731302
• 负责人: Allitia DiBernardo
• 金额: $ 0.57万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7731302
• 关键词: Amyotrophic Lateral Sclerosis; Apoptotic; Brain; Cells; Cessation of life; Computer Retrieval of Information on Scientific Projects Database; Creatine; Data; Dose; Drug Kinetics; Evaluation; Funding; Grant; Institution; Label; Metabolic; Mitochondria; Motor Neurons; Pathway interactions; Play; Research; Research Personnel; Resources; Role; Source; United States National Institutes of Health; dosage; mitochondrial dysfunction

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There are many proposed mechanisms of motor neuron death in ALS, including mitochondrial dysfunction. Mitochondria play a major role in the metabolic and apoptotic pathways of cells. Creatine has shown to stabilize the mitochondrial activity, which makes it appropriate for evaluation in the treatment of ALS. This study will establish pharmacokinetic data and determine if there are increased brain levels of creatine, at escalating doses.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 ALS中运动神经元死亡的机制有很多，包括线粒体功能障碍。线粒体在细胞的代谢和凋亡途径中起主要作用。肌酸已显示出稳定线粒体活性，这使得其适合用于评估ALS的治疗。本研究将建立药代动力学数据，并确定在递增剂量下，肌酸的脑水平是否增加。