FEASIBILITY AND TOLERABILITY OF NALTREXONE AND BACLOFEN FOR ALCOHOL DEPENDENCE

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 本研究将探索4种不同组合的12周方案的可行性和耐受性：1）纳洛酮（50 mg每日一次）+安慰剂巴氯芬+行为疗法（n=10）2）安慰剂纳洛酮+巴氯芬（10 mg tid）+行为疗法（n=10）3）巴氯芬（10 mg tid）+纳洛酮（50 mg每日一次）+行为疗法（n=10）4）安慰剂巴氯芬+安慰剂纳洛酮+行为疗法在酒精戒断的住院医疗戒毒期间招募的酒精依赖成年人中的应用。在研究期间，还将收集酒精依赖受试者的细胞因子水平和神经类固醇水平的探索性数据。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will explore the feasibility and tolerability of a 12-wk regimen of 4 different combinations: 1) naltrexone (50mg once a day) + placebo baclofen + behavioral therapy (n=10) 2) placebo naltrexone + baclofen (10mg tid) + behavior therapy (n=10) 3) baclofen (10 mg tid) + naltrexone (50mg once per day) + behaviour therpay (n=10) 4) placebo baclofen + placebo naltrexone + behavior therapy in adult individuals with alcohol dependence recruited during inpatient medical detoxification for alcohol withdrawal. During the study exporatory data will also be gathered on cytokine levels and neurosteroid levels in subjects with alcohol dependence.