GENOMIC PREDICTORS OF ENDOTHELIAL FUNCTION IN PATIENTS WITH ATHEROSCLEROTIC CARD

动脉粥样硬化患者内皮功能的基因组预测因子

• 批准号: 7716919
• 负责人: CRAIG R LEE
• 金额: $ 0.09万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-02 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716919
• 关键词: African American; Atherosclerosis; Clinical Research; Communities; Computer Retrieval of Information on Scientific Projects Database; Cytochrome P450; Enrollment; Funding; Genetic; Genetic Variation; Genomics; Grant; Human; Individual; Institution; Measurement; Methods; Participant; Pathway interactions; Patients; Peripheral; Procedures; Purpose; Research; Research Personnel; Resources; Source; Ultrasonography; United States National Institutes of Health; Variant; Venous blood sampling; brachial artery; digital; tonometry; vascular inflammation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Purpose: To define the relationship between genetic variation in the P450 epoxygenase pathway, endothelial function and vascular inflammation in humans. Participants: We propose to enroll N=250 (N=150 non-African-American, N=100 African-American) patients with established atherosclerosis, and N=35 healthy individuals from the local Chapel Hill community. Procedures (methods): In the General Clinical Research Center, we propose to (1) assess endothelial function non-invasively by brachial artery ultrasound and digital peripheral arterial tonometry, and (2) collect a venous blood sample for the measurement of markers of vascular inflammation and identification of genetic (DNA) variants in the P450 epoxygenase pathway.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 目的：明确人类 P450 环氧化酶途径的遗传变异、内皮功能和血管炎症之间的关系。 参与者：我们建议招募 N=250（N=150 非非裔美国人，N=100 非裔美国人）患有动脉粥样硬化的患者，以及 N=35 名来自当地的健康个体 教堂山社区。 程序（方法）：在普通临床研究中心，我们建议（1）通过肱动脉超声和数字外周动脉张力测定法无创评估内皮功能，以及（2）收集静脉血样本用于测量血管标志物 炎症和 P450 环氧化酶途径中遗传 (DNA) 变异的鉴定。