GENOMIC PREDICTORS OF ENDOTHELIAL FUNCTION IN PATIENTS WITH ATHEROSCLEROTIC CARD

动脉粥样硬化患者内皮功能的基因组预测因子

• 批准号: 7716919
• 负责人: CRAIG R LEE
• 金额: $ 0.09万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-02 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716919
• 关键词: African American; Atherosclerosis; Clinical Research; Communities; Computer Retrieval of Information on Scientific Projects Database; Cytochrome P450; Enrollment; Funding; Genetic; Genetic Variation; Genomics; Grant; Human; Individual; Institution; Measurement; Methods; Participant; Pathway interactions; Patients; Peripheral; Procedures; Purpose; Research; Research Personnel; Resources; Source; Ultrasonography; United States National Institutes of Health; Variant; Venous blood sampling; brachial artery; digital; tonometry; vascular inflammation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Purpose: To define the relationship between genetic variation in the P450 epoxygenase pathway, endothelial function and vascular inflammation in humans. Participants: We propose to enroll N=250 (N=150 non-African-American, N=100 African-American) patients with established atherosclerosis, and N=35 healthy individuals from the local Chapel Hill community. Procedures (methods): In the General Clinical Research Center, we propose to (1) assess endothelial function non-invasively by brachial artery ultrasound and digital peripheral arterial tonometry, and (2) collect a venous blood sample for the measurement of markers of vascular inflammation and identification of genetic (DNA) variants in the P450 epoxygenase pathway.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目的：明确人类P450表氧化酶通路的遗传变异、内皮功能和血管炎症之间的关系。 参会人员：我们计划入组N=250例（N=150例非非洲裔美国人，N=100例非洲裔美国人）确诊动脉粥样硬化的患者和N=35例来自当地的健康个体。 查佩尔山社区。 程序（方法）：在综合临床研究中心，我们建议（1）通过肱动脉超声和数字外周动脉张力计无创评估内皮功能，（2）收集静脉血样用于测量血管内皮细胞标志物， 炎症和鉴定P450表氧化酶途径中的遗传（DNA）变体。