GENOMIC PREDICTORS OF ENDOTHELIAL FUNCTION IN PATIENTS WITH ATHEROSCLEROTIC CARD

点击翻译按钮获取中文摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Purpose: To define the relationship between genetic variation in the P450 epoxygenase pathway, endothelial function and vascular inflammation in humans. Participants: We propose to enroll N=250 (N=150 non-African-American, N=100 African-American) patients with established atherosclerosis, and N=35 healthy individuals from the local Chapel Hill community. Procedures (methods): In the General Clinical Research Center, we propose to (1) assess endothelial function non-invasively by brachial artery ultrasound and digital peripheral arterial tonometry, and (2) collect a venous blood sample for the measurement of markers of vascular inflammation and identification of genetic (DNA) variants in the P450 epoxygenase pathway.