PHASE II TRIAL ASSESS SFTY OF IMNOSPRSN W/DRAWAL IN LIVER TRNSPLNT RECIP W/HEP C

II 期试验评估 IMNOSPRSN 的 SFTY，并抽取肝脏 TRNSPLNT 配方和 HEP C

• 批准号: 7719492
• 负责人: James F. Trotter
• 金额: $ 0.04万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719492
• 关键词: Adrenal Cortex Hormones; Allografting; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Hepatitis; Hepatitis C; Immunosuppression; Institution; Label; Liver; Liver Failure; Maintenance; Participant; Phase; Randomized; Randomized Controlled Clinical Trials; Recurrence; Research; Research Personnel; Resources; Schedule; Source; Tacrolimus; Therapeutic immunosuppression; Transplantation; United States National Institutes of Health; Withdrawal; liver transplantation; prospective

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a prospective multicenter, open-label, randomized trial in which participants with hepatitis C-related liver failure undergo liver transplantation and receive immunosuppression induction with tacrolimus and corticosteroids. Corticosteroids are tapered in the 3 months after transplantation and tacrolimus is continued. Participants are regularly assessed for recurrence of hepatitis and for evidence of allograft rejection. One year after transplantation, participants suitable for withdrawal are randomly assigned to immunosuppression withdrawal or maintenance. Participants assigned to withdrawal undergo a scheduled taper over 1 year.

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