COFAR 3 EGG ORAL IMMUNOTHERAPY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 超过1100万美国人患有食物过敏。 他们的免疫系统对食物中的某些蛋白质产生负面反应。 在某些情况下，免疫反应是严重的，甚至可能导致死亡。 这个问题影响了美国大约6%的儿童和3.5%的成年人。 据估计，鸡蛋过敏会影响2.6%的3岁以下儿童。 有研究表明，通过食用非常少量的鸡蛋白色固体并在一段时间内逐渐增加，可以最大限度地减少甚至消除对鸡蛋的食物过敏反应。 有些人可以通过这种疗法对鸡蛋产生耐受性，并最终能够再次将鸡蛋纳入饮食中。 本研究旨在确定是否可以在参与并接受积极治疗的受试者中安全地诱导对鸡蛋的脱敏和耐受。 我们预计，在接受积极治疗的患者中，有多达一半的人在完成研究后能够耐受吃鸡蛋，并将在日常饮食中恢复吃鸡蛋。如果成功的话，这项研究将为食物过敏提供第一个突破性的治疗方法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Over 11 million Americans suffer from food allergies. Their immune systems react negatively to certain proteins found in the food. In some cases, the immune reaction is severe and can even cause death. The problem affects approximately 6% of children and 3.5% of adults in the United States. Egg allergy is estimated to affect 2.6% of young children by the age of 3 years. There is research that shows that it is possible to minimize and, in some cases, eliminate a food allergic response to egg by eating very small amounts of egg white solids and increasing gradually over a period of time. Some people can become tolerant of egg by this therapy and may eventually be able to include egg in their diet again. This study is designed to determine if desensitization and tolerance to egg can be safely induced in the subjects who participate and receive active treatment. We expect as many as half of the people who receive active treatment will be able to tolerate eating eggs after completing the study, and will resume eating eggs in their regular diets. If successful, this study will present the first, breakthrough treatment for food allergy.