Tissue Systems Biology for Breast Cancer Prognostic and Predictive Testing

乳腺癌预后和预测测试的组织系统生物学

基本信息

  • 批准号:
    7744772
  • 负责人:
  • 金额:
    $ 14.73万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2009
  • 资助国家:
    美国
  • 起止时间:
    2009-09-28 至 2012-08-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Breast cancer is the most frequently diagnosed type of cancer in women, with 1.3 million new diagnoses and 465,000 deaths annually worldwide. There is an acute need for improved prognostic and predictive tools to aid individualized treatment for breast cancer. Tests are specifically required to identify high risk patients requiring aggressive therapy and monitoring, low risk patients who may be spared unnecessary chemotherapy, and to select specific therapies to which individuals are likely to respond. Such tests are critical to improve disease management and survival rates for breast cancer patients. The long term objective of the project is to develop and commercialize a tissue-based multiplexed immunofluorescence biomarker test for breast cancer to predict clinical outcome and responses to therapies with higher sensitivity and specificity than current diagnostic tools. An optimal panel of biomarkers will be determined using the Tissue Systeumors that can be reduced to decision "indices" with the aid of classifiers constructed from retrospective studies. In Phase I the project specifically aims to retrospectively evaluate a panel of 24 prognostic and predictive functional biomarkers by multiplexed immunofluorescence staining on tissue microarrays of breast tumor tissues from patients with good outcome and patients with poor outcome. Precise intracellular measurements of the biomarkers will be made by quantitative analysis of images generated by fluorescence digital imaging pathology. The biomarker measurements will be correlated with clinical and pathological data to determine an optimal panel of functional biomarkers. Classifier software will be built using the optimal biomarker panel to predict recurrence risk, survival and clinical outcome. The classifier will be the critical solution to convert the complex biomarker data to meaningful indices for prognostic purposes. In the Phase II of the project the utility, speciest as an addition to thecurrent IHC measurements performed at diagnosis tumor tissue sections. Successful development of the test will enable more accurate prognoses and predictions for individualized decision-making and improved disease management for breast cancer. PUBLIC HEALTH RELEVANCE: There is an acute need for improved prognostic and predictive tests to aid individualized management for breast cancer. The proposed research aims to develop a Tissue Systems Biology (CSBTM) profiling test that measures a combination of the key functions of tumors including, the immune system, that control tumor spread and the responses of tumors to cancer therapies. The test will enable more accurate prognoses and predictions of responses to therapies for individual breast cancer patients to improve management of the disease.
描述(由申请人提供):乳腺癌是女性中最常诊断的癌症类型,全球每年有130万例新诊断和465,000例死亡。迫切需要改进的预后和预测工具,以帮助乳腺癌的个体化治疗。特别需要测试,以确定需要积极治疗和监测的高风险患者,低风险患者谁可以省去不必要的化疗,并选择特定的治疗,个人可能会作出反应。这些测试对于改善乳腺癌患者的疾病管理和生存率至关重要。该项目的长期目标是开发和商业化一种基于组织的乳腺癌多重免疫荧光生物标志物检测,以预测临床结果和对治疗的反应,其灵敏度和特异性高于目前的诊断工具。将使用组织系统学确定最佳生物标志物组,该组织系统学可在回顾性研究构建的分类器的帮助下简化为决策“指数”。在第一阶段,该项目的具体目标是回顾性地评估一组24个预后和预测功能生物标志物,通过对来自预后良好和预后不良患者的乳腺肿瘤组织的组织微阵列进行多重免疫荧光染色。将通过荧光数字成像病理学生成的图像的定量分析进行生物标志物的精确细胞内测量。生物标志物测量将与临床和病理学数据相关,以确定功能性生物标志物的最佳组。将使用最佳生物标志物面板构建分类器软件,以预测复发风险,生存率和临床结局。分类器将是将复杂的生物标志物数据转换为用于预后目的的有意义的指数的关键解决方案。在该项目的第二阶段,该实用程序是对目前在诊断肿瘤组织切片上进行的IHC测量的补充。该测试的成功开发将为个性化决策和改善乳腺癌疾病管理提供更准确的诊断和预测。公共卫生相关性:迫切需要改进预后和预测性测试,以帮助乳腺癌的个体化管理。该研究旨在开发一种组织系统生物学(CSBTM)分析测试,该测试测量肿瘤的关键功能组合,包括控制肿瘤扩散的免疫系统和肿瘤对癌症治疗的反应。该测试将能够更准确地评估和预测个体乳腺癌患者对治疗的反应,以改善疾病的管理。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Rebecca Critchley-Thorne其他文献

Rebecca Critchley-Thorne的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Rebecca Critchley-Thorne', 18)}}的其他基金

Stratification of Cancer Risk in Patients with Non-Dysplastic Barrett's Esophagus using TissueCypher: The SCRiBE study
使用 TissueCypher 对非发育性巴雷特食管患者的癌症风险进行分层:SCRiBE 研究
  • 批准号:
    10561001
  • 财政年份:
    2023
  • 资助金额:
    $ 14.73万
  • 项目类别:
TissueCypher Testing for Risk Assessment in Barretts Esophagus
用于 Barretts 食管风险评估的 TissueCypher 测试
  • 批准号:
    8980580
  • 财政年份:
    2015
  • 资助金额:
    $ 14.73万
  • 项目类别:

相似海外基金

Establishment of a method for evaluating automobile driving ability focusing on frontal lobe functions and its application to accident prediction
以额叶功能为中心的汽车驾驶能力评价方法的建立及其在事故预测中的应用
  • 批准号:
    20K07947
  • 财政年份:
    2020
  • 资助金额:
    $ 14.73万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Evaluation of the Effectiveness of Multi-Professional Collaborative Assessment of Cognitive Function and Automobile Driving Skills and Comprehensive Support
认知功能与汽车驾驶技能多专业协同评估效果评价及综合支持
  • 批准号:
    17K19824
  • 财政年份:
    2017
  • 资助金额:
    $ 14.73万
  • 项目类别:
    Grant-in-Aid for Challenging Research (Exploratory)
Development of Flexible Automobile Driving Interface for Disabled People
残疾人灵活汽车驾驶界面开发
  • 批准号:
    25330237
  • 财政年份:
    2013
  • 资助金额:
    $ 14.73万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Automobile driving among older people with dementia: the effect of an intervention using a support manual for family caregivers
患有痴呆症的老年人的汽车驾驶:使用家庭护理人员支持手册进行干预的效果
  • 批准号:
    23591741
  • 财政年份:
    2011
  • 资助金额:
    $ 14.73万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了