ANA/CAT MRKRS IN SKLETL MUSCLE IN RESP TO ANDROGEN DEPRIVATION THERAPY & EXERCIS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们的目标是通过保护老年人的肌肉免受癌症和/或癌症治疗的影响，帮助患有癌症的老年人过上更健康、更有成效的生活。雄激素剥夺疗法(ADT)是前列腺癌的一种常见治疗方法，它极大地降低了血液中性激素睾酮的水平，以保护前列腺。ADT有助于延缓前列腺癌的进展或复发，但它也会导致肌肉的丧失。肌肉的这些变化令人担忧，因为它们会导致虚弱，并可能损害生活质量。此外，男性通常被诊断为前列腺癌的年龄(50-80岁)本身就与肌肉质量和力量的丧失有关。因此，ADT可能会导致老年男性早衰。我们建议阻力运动训练(举重)可以抵消ADT引起的肌肉生物学变化，并导致肌肉质量增加(肥大)。在这项初步研究中，我们将确定阻力运动训练对抵消正在接受ADT的男性肌肉生物学变化的有效性。我们将测量对肌肉分解和生长至关重要的特定基因的变化，以响应ADT和阻力运动训练。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our goal is to help older adults with cancer live healthier, more productive lives by protecting their muscles from the effects of cancer and/or cancer treatment. Androgen-deprivation therapy (ADT), a common treatment for prostate cancer, dramatically reduces the levels of the sex hormone testosterone in the blood to protect the prostate. ADT is beneficial in delaying the progression or recurrence of prostate cancer, but it also causes the loss of muscle. These changes in muscle are troubling because they cause weakness and can impair quality of life. Furthermore, the age at which men are typically diagnosed with prostate cancer (50 - 80 y) is in itself associated with a loss of muscle mass and strength. Thus, ADT may cause premature frailty in older men. We are proposing that resistance exercise training (weight lifting) can offset changes in muscle biology due to ADT and cause an increase in muscle mass (hypertrophy). In this preliminary study, we will determine the effectiveness of resistance exercise training to offset changes in muscle biology in men who have been undergoing ADT. We will measure changes in specific genes important to muscle breakdown and growth in response to ADT and resistance exercise training.