EFFECTS OF ST JOHN?S WORT ON LEVONORGESTREL/EMERGENCY CONTRACEPTION

圣约翰草对左炔诺孕酮/紧急避孕的影响

• 批准号: 7718510
• 负责人: PATRICIA MURPHY
• 金额: $ 2.81万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718510
• 关键词: Age; Blinded; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Contraceptive Agents; Cytochrome P450; Dose; Enzymes; Funding; Grant; Hypericum perforatum; Institution; Levonorgestrel; Liver; Metabolism; Pregnancy; Randomized; Research; Research Personnel; Resources; Source; Steroids; System; Treatment Protocols; United States National Institutes of Health; Woman; emergency contraception; prevent; reproductive

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will evaluate the effects of a common herbal remedy, St. John's Wort (Hypericum perforatum), on metabolism of levonorgestrel in a dosing regimen for emergency contraception. Emergency contraception, if taken soon after unprotected intercourse, prevents pregnancy. St. John's Wort induces the P450 enzyme system in the liver, and may cause increased metabolism of contraceptive steroids used as emergency contraception. This will be a randomized, blinded, clinical trial of four groups of reproductive-aged women to assess the potential interaction between St. John's Wort and levonorgestrel.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究将评估一种常见的草药圣约翰麦芽汁(贯叶连翘)在紧急避孕剂量方案中对左炔诺孕酮代谢的影响。如果在无保护措施的性交后立即采取紧急避孕措施，可以防止怀孕。圣约翰麦芽汁诱导肝脏中的P450酶系统，并可能导致用于紧急避孕的避孕类固醇的代谢增加。这将是一项对四组育龄妇女进行的随机、盲法临床试验，以评估圣约翰麦芽汁和左炔诺孕酮之间的潜在相互作用。