CYTOKINE ACTIVATION AND PROTEIN CATABOLISM IN ESRD

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项应用的主要目的是检查(A)细胞因子激活减少和(B)口服EAA补充和透析内细胞因子激活减少对终末期肾病患者全身蛋白质周转和部分合成(FSR)以及肌肉蛋白质、白蛋白和纤维蛋白原的部分分解(FBR)率的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The principal aims of this appliation are to examine the effect of (a) decreased cytokine activation and (b) combined effect of oral EAA supplementation along with decreased intra-dialytic cytokine activation on whole body protein turnover and fractional synthesis (FSR), and fractional breakdown (FBR) rates of muscle protein, albumin and fibrinogen in ESRD.