MYOCARDIAL SUBSTRATE SELECTION AND SWITCHING IN LEAN AND OBESE HUMANS

瘦人和肥胖人的心肌基质选择和转换

• 批准号: 7717514
• 负责人: Kieren J Mather
• 金额: $ 0.09万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7717514
• 关键词: Applications Grants; Computer Retrieval of Information on Scientific Projects Database; Condition; Data; Diabetes Mellitus; Disease; Fasting; Fatty Acids; Funding; Future; Glucose; Grant; Human; Hyperinsulinism; Institution; Insulin; Insulin Resistance; Measurement; Metabolic Diseases; Metabolism; Myocardial; Myocardial dysfunction; Myocardium; Nonesterified Fatty Acids; Obesity; Perfusion; Positron-Emission Tomography; Protocols documentation; Rate; Research; Research Personnel; Resources; Source; Testing; Tissues; United States National Institutes of Health; Work; fatty acid oxidation; glucose metabolism; oxidation; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The myocardium has the capacity to switch between free fatty acids and glucose as oxidative substrates, in response to changes in substrate supply, work demand, and local and systemic regulators. Disorders of metabolism, such as obesity and diabetes, are associated with increased rates of myocardial dysfunction, and it is possible that alterations in fuel selection underlie this relationship. Comparatively little is known about myocardial fuel selection in the basal state and in response to insulin in these disease states. The current proposal will test the hypothesis that the contribution of fatty acids to overall myocardial metabolism is increased in obese insulin resistant subjects, and that the capacity to switch to glucose metabolism under insulin stimulation is reduced. In the current protocol, we will perform positron emission tomography measurements of myocardial fatty acid oxidation, total oxidation, and tissue perfusion in lean and obese subjects. These studies will be performed under basal fasting conditions, and under steady state conditions of hyperinsulinemia. The resulting data will be used to support a future grant proposal which will explore these questions in more detail.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 心肌有能力在作为氧化底物的游离脂肪酸和葡萄糖之间切换，以响应底物供应、工作需求以及局部和系统调节的变化。代谢紊乱，如肥胖和糖尿病，与心肌功能障碍的发生率增加有关，而燃料选择的变化可能是这种关系的基础。对于基础状态下的心肌能量选择以及这些疾病状态下对胰岛素的反应，人们知之甚少。目前的提议将检验一种假设，即在肥胖的胰岛素抵抗受试者中，脂肪酸对整体心肌代谢的贡献增加，并且在胰岛素刺激下切换到葡萄糖代谢的能力降低。在目前的方案中，我们将对瘦和肥胖受试者的心肌脂肪酸氧化、总氧化和组织血流灌注进行正电子发射断层扫描测量。这些研究将在基础空腹条件下和在高胰岛素血症的稳定状态下进行。所得数据将用于支持未来的赠款提案，该提案将更详细地探讨这些问题。