THE LONGITUDINAL STUDY OF THE OCULAR COMPLICATIONS OF AIDS

艾滋病眼部并发症的纵向研究

• 批准号: 7724998
• 负责人: Baruch Davidson Kuppermann
• 金额: $ 7.41万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7724998
• 关键词: Acquired Immunodeficiency Syndrome; Biochemical; California; Characteristics; Clinical; Computer Retrieval of Information on Scientific Projects Database; Cytomegalovirus Retinitis; Face; Funding; Grant; Immune; Incidence; Infection; Institution; Longitudinal Studies; Monitor; Multicenter Trials; Observational Study; Ophthalmology; Patients; Population; Publications; Quality of life; Research; Research Design; Research Personnel; Resources; Risk; Source; United States National Institutes of Health; Universities; Vision; Writing; lectures; professor; prospective; treatment effect; trend

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Longitudinal Study of the Ocular Complications of AIDS (LSOCA) is a prospective, observational study designed to provide information on the incidence and course of ocular complications of AIDS in the face of changing anti-HIV and anti-CMV therapies. The objectives are: " To monitor secular trends in the incidence of CMV retinitis and other ocular complications of AIDS " To determine the effect of HAART-induced changes in immune status on the risk of CMV retinitis and other ocular complications of AIDS. " To determine the characteristics (clinical, virologic, hematologic, and biochemical) of populations at high risk for CMV retinitis and other ocular complications of AIDS. " To evaluate the effects of treatments for CMV retinitis and other ocular complications on visual function, quality of life, and survival. This study is being performed as a part of a multicenter trial group funded by the NIH/NEI called the Studies of the Ocular Complications of AIDS (SOCA). 2. BACKGROUND OF THE INVESTIGATOR: Dr. Kuppermann is an Associate Professor in the Department of Ophthalmology at the University of California, Irvine. Dr. Kuppermann has written and lectured extensively on the management of CMV retinitis and other infections in AIDS patients. Recent publications include:

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 艾滋病眼部并发症的纵向研究（LSOCA）是一项前瞻性、观察性研究，旨在提供关于艾滋病眼部并发症的发病率和病程的信息，以应对不断变化的抗HIV和抗CMV治疗。 其目标是： " 监测巨细胞病毒视网膜炎和艾滋病其他眼部并发症发病率的长期趋势 " 确定HAART诱导的免疫状态变化对CMV视网膜炎和其他AIDS眼部并发症风险的影响。 " 确定CMV视网膜炎和其他AIDS眼部并发症高危人群的特征（临床、病毒学、血液学和生化）。 " 评价CMV视网膜炎和其他眼部并发症的治疗对视功能、生活质量和生存率的影响。 这项研究是由NIH/NEI资助的多中心试验组的一部分，称为艾滋病眼部并发症研究（SOCA）。 2.制冷机的背景： 博士Kuppermann是加州大学欧文分校眼科学系的副教授。 Kuppermann博士曾撰写并发表大量关于艾滋病患者CMV视网膜炎和其他感染的管理的演讲。 最近的出版物包括：