NEURAL RESPONSE TO ADVERTISING CUES IN ADOLESCENTS: A PILOT FMRI STUDY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 尼古丁依赖被认为是成瘾吸烟行为的一个潜在因素(Chiamulera，2005)。源于成瘾理论的实验方法着眼于非药理学因素的影响，特别是与药物相关的刺激对吸毒行为的影响。在成瘾理论中，环境线索通常被认为是成瘾行为的可能增强剂。线索反应性是基于一种假设，即吸毒者比非吸毒者更容易对与毒品相关的刺激做出反应，如视觉、嗅觉、听觉、触觉等(Chiamulera 2005)。线索反应范式主要被理解为经典条件作用的结果(Carter和Tiffany，1999)。 除了赌博等其他成瘾行为外，还对成年人进行了线索反应性研究，并显示了与不使用酒精、尼古丁和其他物质的成年人在心理、认知和神经方面的不同影响(Carter和Tiffany 1999；Chiamulera 2005；George等人)。2001年；McDermut和Haaga，1998年；Potenza等人。2003年)。在青少年中，使用功能磁共振成像(FMRI)对患有酒精使用障碍(AUD)的受试者进行了线索反应的检测(Tapert等人)。2003年)。青少年对环境刺激反应的神经机制尚不完全清楚，尤其是在广告意象的影响方面。本研究的目的是使用功能磁共振成像来分析青少年对香烟广告的神经反应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Nicotine dependence is believed to be an underlying factor in addictive smoking behavior (Chiamulera 2005). Experimental approaches derived from addiction theory have looked at the effect of non-pharmacological factors, specifically drug-related stimuli on drug-taking behavior. Environmental cues are often indicated in addiction theory as a possible reinforcer of addictive behavior. Cue reactivity is based on the hypothesis that drug users are predisposed to react to drug-related stimuli such as visual, olfactory, auditory, tactile, etc. versus non-drug users (Chiamulera 2005). The cue reactivity paradigm is primarily understood as an effect of classical conditioning (Carter and Tiffany 1999). Cue reactivity studies have been conducted on adults with alcohol, nicotine and other substances in addition to other addictive behaviors, such as gambling, and have shown differential psychological, cognitive and neural effects versus adults who are non-users (Carter and Tiffany 1999; Chiamulera 2005; George et al. 2001; McDermut and Haaga 1998; Potenza et al. 2003). In adolescents, cue reactivity has been examined using functional magnetic resonance imaging (fMRI) with subjects suffering from Alcohol Use Disorder (AUD) (Tapert et al. 2003). The neural mechanism underlying cue reactivity in response to environmental stimuli in adolescents is not fully understood, especially in regard to the effect of advertising imagery. The purpose of the current study is to use fMRI to analyze neural responses to cigarette advertising in adolescents.