Risk Assessment and Tailored Intervention to Improve CPAP Adherence

描述（由申请人提供）：候选人的总体长期职业目标是成为一名独立研究者，专注于量身定制的干预措施，以促进研究密集型大学环境中 CPAP 的坚持。为了实现这一目标，候选人确定以下近期职业目标； (1) 完善和验证风险评估工具，以前瞻性地识别因不遵守 CPAP 治疗而面临高风险的新诊断 OSA 患者； (2) 积极参加培训计划，该计划将提供成功进行随机对照试验（RCT）的知识和技能，以测试定制的依从性促进干预措施的效果； (3) 在同行评审的环境中传播拟议的初步研究和初步研究 (ROO) 的结果，为风险评估和 CPAP 依从性干预措施领域的科学文献做出贡献； (4) 寻​​求职业发展机会，进入研究型大学的终身教职、初级教职职位； (5) 接受负责任的研究领域的培训。候选人提出的培训计划提供了示范性的资源和机会，以实现近期职业目标并成功开展拟议的研究。该研究项目是一项随机对照试验，旨在测试研究者开发的、量身定制的 CPAP 坚持促进干预措施的效果。将使用研究者开发的风险评估工具来测量不遵守 CPAP 的治疗前风险。高风险非依从者将被随机分配到干预组或对照组。主要结果变量，CPAP 坚持性，将在一周和三个月时进行检查。拟议的培训计划侧重于几个培训领域，以支持成功完成拟议的研究和未来提交 R01 申请：（1）不遵守 CPAP 的风险评估； (2) 结合行为理论原则制定量身定制的干预措施； (3) 随机对照试验方法、实施和分析。宾夕法尼亚大学是一个资源丰富、堪称典范的培训环境，可以参与个性化培训计划，该培训计划具有跨学科重点，并与国际知名专家建立指导关系，可全面满足申请人的培训需求。

Description (Provided by Applicant): The candidate's overall long-term career goal is to become an independent investigator focusing on tailored interventions to promote CPAP adherence in a research-intensive university environment. To fulfill this goal, the candidate identifies the following immediate career goals; (1) refine and validate a risk assessment instrument to prospectively identify newly-diagnosed OSA patients at high risk for non adherence to CPAP; (2) actively participate in a training program which will provide the knowledge and skill to successfully conduct a randomized controlled trial (RCT) pilot-testing the effect of a tailored adherence promotion intervention; (3) disseminate results of proposed preliminary studies and the primary study (ROO) in peer reviewed settings, contributing to the scientific literature in the areas of risk assessment and CPAP adherence interventions; (4) pursue opportunities for career advancement into a tenure-track, entry-level faculty position at a research-intensive university; and (5) acquire training in the area of responsible conduct of research. The candidate's proposed training plan provides exemplary resources and opportunities to achieve the immediate career goals and successfully conduct the proposed research. The research project is a RCT to test the effect of an investigator-developed, tailored CPAP adherence promotion intervention. Pre-treatment risk for non adherence to CPAP will be measured using the investigator-developed risk assessment tool. High risk non adherers will be randomized to the intervention or control group. The primary outcome variable, CPAP adherence, will be examined at one week and three months. The proposed training plan focuses on several areas of training to support successful completion of the proposed research and future submission of an R01 application: (1) risk assessment of CPAP non adherence; (2) tailored intervention development incorporating behavior theory principles; and (3) randomized controlled trial methods, conduct, and analysis. The University of Pennsylvania is an exemplary, resource-rich, training environment to participate in an individualized training plan with an interdisciplinary focus and mentoring relationships with internationally-esteemed experts that summarily address the applicant's training needs.