Risk Assessment and Tailored Intervention to Improve CPAP Adherence

描述(由申请人提供)：应聘者的总体长期职业目标是成为一名独立调查员，专注于在研究密集型大学环境中促进CPAP遵守的量身定制的干预措施。为了实现这一目标，候选人确定了以下直接的职业目标：(1)完善和验证风险评估工具，以前瞻性地识别新诊断的OSA患者不遵守CPAP的高风险；(2)积极参与培训计划，该培训计划将提供知识和技能，以成功地进行随机对照试验(RCT)试点-测试定制依从性促进干预的效果；(3)在同行评议的环境中传播拟议的初步研究和初步研究(ROO)的结果，为风险评估和CPAP遵守干预领域的科学文献做出贡献；(4)寻求在研究密集型大学获得终身教职、初级教员职位的机会；以及(5)接受负责任的研究领域的培训。候选人提出的培训计划提供了模范的资源和机会，以实现眼前的职业目标并成功开展拟议的研究。这项研究项目是一项随机对照试验，旨在测试研究人员开发的、量身定做的CPAP遵从性促进干预的效果。不遵守CPAP的治疗前风险将使用调查人员开发的风险评估工具进行衡量。高危未依从者将被随机分为干预组或对照组。主要结果变量，CPAP依从性，将在一周和三个月时进行检查。拟议的培训计划侧重于几个培训领域，以支持成功完成拟议研究和未来提交R01申请：(1)未遵守CPAP的风险评估；(2)结合行为理论原则的量身定做的干预发展；以及(3)随机对照试验方法、实施和分析。宾夕法尼亚大学是一个模范的、资源丰富的培训环境，可以参与个性化的培训计划，重点是跨学科，并与国际上受尊敬的专家建立指导关系，简要地满足申请者的培训需求。

Description (Provided by Applicant): The candidate's overall long-term career goal is to become an independent investigator focusing on tailored interventions to promote CPAP adherence in a research-intensive university environment. To fulfill this goal, the candidate identifies the following immediate career goals; (1) refine and validate a risk assessment instrument to prospectively identify newly-diagnosed OSA patients at high risk for non adherence to CPAP; (2) actively participate in a training program which will provide the knowledge and skill to successfully conduct a randomized controlled trial (RCT) pilot-testing the effect of a tailored adherence promotion intervention; (3) disseminate results of proposed preliminary studies and the primary study (ROO) in peer reviewed settings, contributing to the scientific literature in the areas of risk assessment and CPAP adherence interventions; (4) pursue opportunities for career advancement into a tenure-track, entry-level faculty position at a research-intensive university; and (5) acquire training in the area of responsible conduct of research. The candidate's proposed training plan provides exemplary resources and opportunities to achieve the immediate career goals and successfully conduct the proposed research. The research project is a RCT to test the effect of an investigator-developed, tailored CPAP adherence promotion intervention. Pre-treatment risk for non adherence to CPAP will be measured using the investigator-developed risk assessment tool. High risk non adherers will be randomized to the intervention or control group. The primary outcome variable, CPAP adherence, will be examined at one week and three months. The proposed training plan focuses on several areas of training to support successful completion of the proposed research and future submission of an R01 application: (1) risk assessment of CPAP non adherence; (2) tailored intervention development incorporating behavior theory principles; and (3) randomized controlled trial methods, conduct, and analysis. The University of Pennsylvania is an exemplary, resource-rich, training environment to participate in an individualized training plan with an interdisciplinary focus and mentoring relationships with internationally-esteemed experts that summarily address the applicant's training needs.