PACTG 1055: PSYCHIATRIC CO-MORBIDITY IN PERINATALLY HIV -INFECTED CHILDREN

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究是一项多中心、观察性研究（意味着将收集信息，但本研究不包括治疗）。它的目的是更好地了解艾滋病毒对一组围产期艾滋病毒感染的儿童和青少年的精神症状的发展的影响，与一组相同年龄，种族和性别的儿童和青少年相比。 通过观察儿童和青少年群体，这项研究将产生可能有助于我们了解艾滋病毒感染对儿童和青少年心理健康影响的信息。这项研究将比较未感染艾滋病毒的儿童和青少年与感染艾滋病毒的儿童和青少年，以更好地了解这一重要人群的精神症状的发展或病程。 由于全世界感染艾滋病毒的儿童和青少年人数众多，这一信息尤其重要。 以前的研究已经检查了破坏性行为障碍的风险因素（即，ADHD、ODD、品行障碍[CD]）和焦虑/抑郁障碍已经确定了这两组疾病共同的风险因素。 除了儿童精神障碍的标准风险外，评估儿童和青少年感染艾滋病毒的许多风险因素的研究还必须考虑嗜神经病毒的终身存在（一种对神经组织有亲和力或局限于神经组织的病毒），具有显著毒性的药物（其中许多是第一次了解）、家族性精神病问题和混乱的生活条件。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is a multicenter, observational study (meaning that information will be collected but there is no treatment as part of this study). It is designed to better understand the impact of HIV on the development of psychiatric symptoms in a group of perinatally HIV-infected children and adolescents, when compared to a group of children and adolescents of the same age, race and gender. By looking at groups of children and adolescents, the study will generate information that may help us understand the effects of HIV infection on the mental health of children and adolescents. The study will compare uninfected children and adolescents with HIV-infected children and adolescents to better understand the development or course psychiatric symptoms in this important, population. This information is particularly important because of the number of HIV-infected children and adolescents worldwide. Previous studies which have examined risk factors for disruptive behavior disorders (i.e., ADHD, ODD, Conduct Disorder [CD]) and anxiety/depressive disorders have identified risk factors common to both groups of disorders. In addition to the standard risks for childhood mental disorders, studies evaluating the many risk factors associated with HIV infection in children and adolescents must also account for life-long presence of a neurotropic virus (a virus which has an affinity for or localizes in nerve tissue), medications that have significant toxicities (many of which are being learned about for the first time), familial psychiatric issues, and disordered living conditions.