CRANIOFACIAL FEATURES NORMATIVE DATABASE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们建议开发一个规范的数据库的3D图像从150个人谁没有诊断颅面疾病。 建立这一规范性数据库有两个目的。 主要目的是描述没有颅面疾病的儿童和年轻人的典型颅面特征。 我们将通过进行人体测量和对3D图像进行形状分析来实现这一点。 第二个目的是量化典型儿童和诊断颅面差异的儿童之间颅面特征的差异。 我们将通过比较正常数据与颅面差异儿童的测量结果来做到这一点。 3D图像的规范数据库的开发将建立在数据收集的基础上，数据收集是我们在颅面研究中心进行的2项先前研究的一部分。 我们目前建议收集的规范性数据将立即用于这些研究之一的继续，在这些研究中，我们将确定22q11.2缺失综合征患者的颅面特征。 更广泛地说，我们目前建议收集的规范性数据将是一个宝贵的资源，在未来用于调查颅面变化的各种颅面疾病。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We propose to develop a normative database of 3D images from 150 individuals who have no diagnosed craniofacial disorders. The purpose of creating this normative database is two-fold. The primary aim is to characterize typical craniofacial features in children and young adults without craniofacial disorders. We will accomplish this by taking anthropometric measurements and performing shape analysis of the 3D images. The second aim is to quantify differences in craniofacial characteristics between typical children and those with diagnosed craniofacial differences. We will do this by comparing the normative data to measurements obtained in children with craniofacial differences. The development of a normative database of 3D images will build upon data collection begun as part of 2 prior studies that we have conducted in the craniofacial research center. The normative data we currently propose to collect will be immediately useful in a continuation of one of those studies, in which we will identify the craniofacial features affected in individuals with 22q11.2 deletion syndrome. More broadly, the normative data we currently propose to collect will be an invaluable resource to be used in the future for investigating craniofacial variation in a wide variety of craniofacial disorders.