SAGITTAL SYNOSTOSIS: 3D PHOTOGRAPHY PROJECT

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项初步研究是为了确定在矢状面融合患者及其亲属中观察到的头部形状差异的最佳方法。在这项研究中收集和分析的数据将被用作一个更大的研究方案的初步数据，以确定矢状面融合的原因。矢状面联会导致肩头畸形，这是一种细长的头部形状，额头突出，枕骨狭窄隆起。在少数家庭中，更多的亲属被诊断为矢状面联结。一些家庭报告有细长的头或大的额头的家庭成员，他们没有被诊断为矢状面联结。我们认为矢状面融合是一种受遗传和环境因素影响的复杂疾病。目前，矢状面融合的原因很大程度上还不清楚。开发一种可重复和准确的头部形状三维测量将对未来确定矢状面融合的遗传原因的研究具有重要意义。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This pilot study is being done to determine the best method of characterizing head shape differences observed in individuals with sagittal synostosis and their relatives. Data collected and analyzed in this study will be used as preliminary data in a larger research proposal to identify causes of sagittal synostosis. Sagittal synostosis results in scaphocephaly, a long narrow head shape with a prominent forehead and narrow bulging occiput. In a few families, additional relatives have been diagnosed with sagittal synostosis. Some families have reported family members with long narrow heads or large foreheads, who have not been diagnosed with sagittal synostosis. We propose that sagittal synostosis is a complex condition due to genetic and environmental factors. At this time causes of sagittal synostosis are largely unexplained. Development of a reproducible and accurate three-dimensional measure of head shape will be important for future studies to identify genetic causes of sagittal synostosis.