GENETIC ANALYSIS OF PSORIASIS AND PSORIATIC ARTHRITIS

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 我们从之前的研究中知道，基因在决定谁患有牛皮癣和/或牛皮癣关节炎方面发挥着重要作用。 本研究的目的是了解银屑病和银屑病关节炎的遗传基础。 为了实现这一目标，我们正在寻找具有这些病症的“家族遗传”的特定基因变异（等位基因），或者在病例（患有这些病症的人）中比在对照（没有这些病症的健康人）中更常见的基因变异（等位基因）。 我们将研究银屑病关节炎患者或有多位家庭成员患有银屑病关节炎的受试者。 我们还将研究患有牛皮癣但没有关节炎的患者。 由于银屑病关节炎的不同模式已被描述，我们将收集有关关节炎的详细信息，以确定某些特征是否与特定的遗传模式相关。 评估将包括：收集有关关节炎和银屑病症状和诊断的历史信息、家族史以及可能伴随银屑病关节炎的相关特征；皮肤损伤和关节炎的物理评估；关节炎的影像学检查，包括下脊柱和骶髂关节的 X 光检查以及膝盖和脚踝的超声检查，以发现这些部位的肌腱和韧带附着处是否存在异常。 我们将从每个受试者身上抽取一份血液样本进行测试，以表征关节炎的活动和类型，并提供用于进行 DNA 研究的细胞。 作为这项研究的一部分，不会提供针对银屑病或银屑病关节炎的治疗。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We know from previous studies that genes play an important role in determining who gets psoriasis and/or psoriatic arthritis. The purpose of this study is to understand the genetic basis of psoriasis and psoriatic arthritis. To accomplish this, we are looking for specific gene variants (alleles) that "run in families" with these conditions, or are found more often in cases (people with these conditions) than in controls (healthy people without either of these conditions). We will study patients with psoriatic arthritis, or subjects who have multiple family members who have psoriatic arthritis. We will also study patients with psoriasis but no arthritis. Because different patterns of psoriatic arthritis have been described, we will collect detailed information about arthritis to determine whether certain features associate with particular genetic patterns. Evaluation will include: collection of historical information about symptoms and diagnosis of arthritis and psoriasis, family history, and associated features that can accompany psoriatic arthritis; physical assessment of skin lesions and of arthritis; imaging studies of arthritis including x-rays of the lower spine and sacroiliac joints along with ultrasound examination of knees and ankles to find any abnormalities at the attachments of tendons and ligaments at these sites. From each subject we will take one blood sample for tests to characterize activity and type of arthritis and to provide the cells on which DNA studies will be done. No treatment for psoriasis or psoriatic arthritis will be provided as part of this study.'