GENETIC ANALYSIS OF PSORIASIS AND PSORIATIC ARTHRITIS

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 我们从以前的研究中知道，基因在决定谁患银屑病和/或银屑病关节炎方面起着重要作用。 本研究的目的是了解银屑病和银屑病关节炎的遗传基础。 为了实现这一目标，我们正在寻找特定的基因变异（等位基因），这些基因变异（等位基因）在这些条件下“在家庭中运行”，或者在病例（患有这些条件的人）中比对照组（没有这些条件的健康人）中更常见。 我们将研究银屑病关节炎患者，或有多个家族成员患有银屑病关节炎的受试者。 我们还将研究银屑病但没有关节炎的患者。 由于银屑病关节炎的不同模式已被描述，我们将收集有关关节炎的详细信息，以确定某些特征是否与特定的遗传模式相关。 评价将包括：收集关于关节炎和银屑病的症状和诊断、家族史和可能伴随银屑病关节炎的相关特征的历史信息;皮肤损伤和关节炎的物理评估;关节炎的成像研究，包括下脊柱和骶髂关节的X射线沿着膝盖和脚踝的超声检查，以发现这些部位的肌腱和韧带附着处的任何异常。 我们将从每名受试者中采集一份血液样本进行测试，以表征关节炎的活动和类型，并提供将进行DNA研究的细胞。 本研究不提供银屑病或银屑病关节炎治疗。'

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We know from previous studies that genes play an important role in determining who gets psoriasis and/or psoriatic arthritis. The purpose of this study is to understand the genetic basis of psoriasis and psoriatic arthritis. To accomplish this, we are looking for specific gene variants (alleles) that "run in families" with these conditions, or are found more often in cases (people with these conditions) than in controls (healthy people without either of these conditions). We will study patients with psoriatic arthritis, or subjects who have multiple family members who have psoriatic arthritis. We will also study patients with psoriasis but no arthritis. Because different patterns of psoriatic arthritis have been described, we will collect detailed information about arthritis to determine whether certain features associate with particular genetic patterns. Evaluation will include: collection of historical information about symptoms and diagnosis of arthritis and psoriasis, family history, and associated features that can accompany psoriatic arthritis; physical assessment of skin lesions and of arthritis; imaging studies of arthritis including x-rays of the lower spine and sacroiliac joints along with ultrasound examination of knees and ankles to find any abnormalities at the attachments of tendons and ligaments at these sites. From each subject we will take one blood sample for tests to characterize activity and type of arthritis and to provide the cells on which DNA studies will be done. No treatment for psoriasis or psoriatic arthritis will be provided as part of this study.'