GENETIC ANALYSIS OF PSORIASIS AND PSORIATIC ARTHRITIS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们从以前的研究中了解到，基因在决定谁患牛皮癣和/或牛皮癣关节炎方面发挥着重要作用。本研究的目的是了解银屑病和银屑病关节炎的遗传基础。为了做到这一点，我们正在寻找患有这些疾病的特定基因变种(等位基因)，或者在病例(患有这些疾病的人)中比在对照组(没有这两种疾病的健康人)中更容易发现。我们将研究牛皮癣关节炎患者，或有多个家庭成员患有牛皮癣关节炎的受试者。我们还将研究患有牛皮癣但没有关节炎的患者。由于牛皮癣关节炎的不同类型已被描述，我们将收集有关关节炎的详细信息，以确定某些特征是否与特定的遗传模式有关。评估将包括：收集有关关节炎和牛皮癣的症状和诊断、家族史和可能伴随牛皮癣关节炎的相关特征的历史信息；对皮肤损害和关节炎进行身体评估；对关节炎进行成像研究，包括对下脊柱和骶骨关节进行X光检查，以及对膝盖和脚踝进行超声波检查，以发现这些部位的肌腱和韧带附着处的任何异常。我们将从每个受试者身上抽取一份血液样本进行测试，以确定关节炎的活动和类型，并提供将进行DNA研究的细胞。这项研究不会提供牛皮癣或牛皮癣关节炎的治疗。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We know from previous studies that genes play an important role in determining who gets psoriasis and/or psoriatic arthritis. The purpose of this study is to understand the genetic basis of psoriasis and psoriatic arthritis. To accomplish this, we are looking for specific gene variants (alleles) that "run in families" with these conditions, or are found more often in cases (people with these conditions) than in controls (healthy people without either of these conditions). We will study patients with psoriatic arthritis, or subjects who have multiple family members who have psoriatic arthritis. We will also study patients with psoriasis but no arthritis. Because different patterns of psoriatic arthritis have been described, we will collect detailed information about arthritis to determine whether certain features associate with particular genetic patterns. Evaluation will include: collection of historical information about symptoms and diagnosis of arthritis and psoriasis, family history, and associated features that can accompany psoriatic arthritis; physical assessment of skin lesions and of arthritis; imaging studies of arthritis including x-rays of the lower spine and sacroiliac joints along with ultrasound examination of knees and ankles to find any abnormalities at the attachments of tendons and ligaments at these sites. From each subject we will take one blood sample for tests to characterize activity and type of arthritis and to provide the cells on which DNA studies will be done. No treatment for psoriasis or psoriatic arthritis will be provided as part of this study.'