THE EFFECTS OF AGE, GENDER, AND RACE ON THE METABOLISM OF ANTIEPILEPTIC DRUGS

年龄、性别和种族对抗癫痫药物代谢的影响

• 批准号: 7603620
• 负责人: PAGE PENNEL
• 金额: $ 0.9万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603620
• 关键词: Alleles; Antiepileptic Agents; Carbamazepine; Computer Retrieval of Information on Scientific Projects Database; Dose; Drug Kinetics; Elderly; Funding; Gender; Grant; Half-Life; Institution; Isotopes; Label; Metabolism; Race; Research; Research Personnel; Resources; Source; United States National Institutes of Health; age effect

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study seeks to characterize the effects of advancing age, gender, and race on carbamazepine (CBZ) pharmacokinetics and metabolism utilizing an IV dose of a stable-labeled CBZ isotope. This study will also seek to determine if subjects homozygous or heterozygous for the CYP3A5*1 allele have an increased CBZ clearance and a faster elimination half-life.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究旨在通过静脉注射稳定标记的卡马西平（CBZ）同位素，研究年龄、性别和种族对CBZ药代动力学和代谢的影响。 本研究还将试图确定CYP 3A 5 *1等位基因纯合子或杂合子受试者是否具有增加的CBZ清除率和更快的消除半衰期。