THE EFFECTS OF AGE, GENDER, AND RACE ON THE METABOLISM OF ANTIEPILEPTIC DRUGS

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 本研究旨在利用静脉注射剂量的稳定标记的 CBZ 同位素来表征年龄、性别和种族的增长对卡马西平 (CBZ) 药代动力学和代谢的影响。 这项研究还将寻求确定 CYP3A5*1 等位基因纯合或杂合的受试者是否具有增加的 CBZ 清除率和更快的消除半衰期。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study seeks to characterize the effects of advancing age, gender, and race on carbamazepine (CBZ) pharmacokinetics and metabolism utilizing an IV dose of a stable-labeled CBZ isotope. This study will also seek to determine if subjects homozygous or heterozygous for the CYP3A5*1 allele have an increased CBZ clearance and a faster elimination half-life.