Animals Models Core

动物模型核心

• 批准号: 7976008
• 负责人: Qing Yi
• 金额: $ 6.41万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7976008
• 关键词: Animal Model; Animals; Cancer Center; Cell Line; Cells; Clinic; Clinical; Disease; Engraftment; Environment; Goals; Grant; Heterogeneity; Human; Human Resources; Institutes; Institution; Laboratories; Lymphoma; Molecular Target; Multiple Myeloma; Patients; Reproduction spores; Research; Research Personnel; SCID-hu Mice; Sampling; Services; Tissue Banking; Tissue Banks; Translational Research; Work; animal facility; clinically relevant; in vivo; mouse model; novel; programs

The main goal of this Myelonna SPORE program is to develop novel targeted therapies to more effectively treat patients with multiple myeloma (MM). Clinically relevant animal models are crucial for examining the in vivo efficacy of novel agents. The dedicated personnel and facilities of the Animal Models Core (Core D) provide the program with clinically relevant animal models and expertise in animal studies essential to achieving the aims ofthe Projects. Core personnel work closely with SPORE investigators to plan animal studies and to develop optimal and clinically relevant mouse models of myeloma. During the past 5 years, the Department of Lymphoma and Myeloma and M. D. Anderson Cancer Center have provided excellent conditions in terms of access to primary myeloma samples, myeloma tissue bank, interaction between clinical and translational research programs, and animal facilities for providing unique, clinically relevant samples to establish myeloma SCID and SCID-hu mouse models, which allow reproducibly engraftment of established human myeloma cell lines or primary myeloma cells freshly isolated from patients with MM, respectively. Establishment of myeloma in SCID-hu mice induces typical human MM manifestations including disease heterogeneity commonly seen in the clinic. The Animal Models Core is well suited to provide expertise and mouse models for the SPORE given that the Animal Models Core Personnel, animal facilities, and tissue banks are all located within the South Campus Research Buildings of our institution where our laboratories are concentrated. This provides a level of integration for the Core that will maximize uniformity and use of available animal models and patients' materials by SPORE investigators.

该Myelonna SPORE计划的主要目标是开发新的靶向疗法， 治疗多发性骨髓瘤（MM）患者。临床相关的动物模型对于研究在 新药剂的体内功效。动物模型核心（核心D）的专用人员和设施 提供临床相关的动物模型和动物研究的专业知识， 实现项目目标。核心人员与SPORE研究人员密切合作， 研究和开发最佳的和临床相关的骨髓瘤小鼠模型。在过去的五年里， 淋巴瘤和骨髓瘤科和M. D.安德森癌症中心提供了极好的 获得原发性骨髓瘤样本、骨髓瘤组织库、 临床和转化研究项目，以及提供独特的，临床相关的动物设施， 样品以建立骨髓瘤SCID和SCID-hu小鼠模型，其允许可重复地植入 建立的人骨髓瘤细胞系或从MM患者新鲜分离的原代骨髓瘤细胞， 分别在SCID-hu小鼠中建立骨髓瘤诱导典型的人类MM表现 包括临床上常见的疾病异质性。动物模型核心非常适合于 为SPORE提供专业知识和小鼠模型，因为动物模型核心人员、动物 设施和组织库都位于我们机构的南校区研究大楼内 我们的实验室都集中在那里这为核心提供了一个集成级别， SPORE研究者对可用动物模型和患者材料的一致性和使用。