EEG coherence in children with TS: Association with ADHD and tic severity

TS 儿童脑电图一致性：与 ADHD 和抽动严重程度的关联

• 批准号: 8303522
• 负责人: DENIS G SUKHODOLSKY
• 金额: $ 8.29万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-03-15 至 2014-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8303522
• 关键词: 12 year old; 6 year old; Address; Adult; Affect; Area; Attention deficit hyperactivity disorder; Autopsy; Biological Markers; Child; Childhood; Communities; Control Groups; Corpus striatum structure; Cross-Sectional Studies; Development; Disease; Disinhibition; Distress; Electrodes; Electroencephalography; Etiology; Event; Foundations; Frequencies; Future; General Population; Gilles de la Tourette syndrome; Goals; Impairment; Individual; Knowledge; Longitudinal Studies; Magnetic Resonance Imaging; Medial; Minority; Modeling; Motor; Motor Cortex; Motor Tics; Neuronal Plasticity; Patients; Performance; Reporting; Research; Schizophrenia; Severities; Signal Transduction; Suggestion; System; Technology; Thalamic structure; Time; Validation; Vocal Tics; base; cognitive control; density; early adolescence; frontal lobe; indexing; inhibitory neuron; neural circuit; neurobiological mechanism; neuromechanism; neuropsychiatry; response

DESCRIPTION (provided by applicant): This is a proposal to investigate mesial-frontal EEG coherence during performance of a Go/No-Go task of motor response inhibition as a biomarker of tic severity and tic suppression in children with Tourette Syndrome (TS). TS is a neuropsychiatric disorder of childhood onset which is characterized by multiple motor and vocal tics. Tics usually appear around 6 years of age, multiply and worsen in number and complexity, and reach the period of worst severity between 10 and 12 years of age. Afterward, tics follow a remitting course in many individuals, remain stable in some or continue to worsen in a minority. Patients who show a remitting course of tics may have successfully developed a compensatory neurobiological mechanism of tic suppression. One study in adults with TS (Serrien et al., 2005) reported increased mesial-frontal EEG coherence in the alpha frequency band during a task of motor response inhibition and it was suggested that this increase represents a mechanism of tic suppression. This study will examine EEG alpha coherence during a task of motor response inhibition in 8 to 12 year old children with TS versus matched unaffected community controls. This proposal builds on the findings of Serrien and colleagues as well as on our own pilot findings of inverse association between EEG alpha coherence and tic severity. In addition, because TS often co-occurs with ADHD, a disorder associated with poor response inhibition, we will also compare children with TS without co-occurring ADHD to children with TS and ADHD. To confirm that the difference between children with TS with and without ADHD is indeed due to ADHD, we will include a control group of children with ADHD without tics. Hence, this is a cross-sectional study involving four groups of subjects: 20 children with TS without ADHD, 20 children with co-occurring TS and ADHD, 20 children with ADHD without tics, and 20 matched healthy community controls. The validation of EEG alpha coherence as a biomarker of tics and tic suppression in this cross-sectional study will create a foundation for developing mechanism-based treatments for TS and for planning longitudinal studies to chart the course of this disorder. PUBLIC HEALTH RELEVANCE: The goal of this study is to examine biomarkers of tic severity and tic suppression in TS, a neuropsychiatric disorder of childhood onset characterized by motor and phonic tics and affecting approximately 0.6 percent of children in the general population. Discovery and validation of biomarkers of tics will promote understanding of a remitting versus a persistent course of TS and the development of mechanism-driven treatments.

描述（由申请方提供）：这是一项研究在进行运动反应抑制的Go/No-Go任务期间近中-额叶EEG相干性的提案，作为抽动秽语综合征（TS）儿童抽动严重程度和抽动抑制的生物标志物。TS是一种儿童期发病的神经精神疾病，以多发性运动和发声抽动为特征。抽搐通常出现在6岁左右，在数量和复杂性上成倍增加和恶化，并在10至12岁之间达到最严重的时期。之后，抽搐在许多人中遵循缓解过程，在一些人中保持稳定或在少数人中继续恶化。抽搐缓解的患者可能已经成功地发展了一种代偿性的神经生物学机制来抑制抽搐。在患有TS的成人中的一项研究（Serrien等人，2005）报道了在运动反应抑制的任务期间α频带中的近中-额叶EEG相干性增加，并且有人认为这种增加代表了抽动抑制的机制。本研究将在8至12岁TS儿童与匹配的未受影响的社区对照组中检查运动反应抑制任务期间的EEG α相干性。这个建议建立在Serrien及其同事的研究结果以及我们自己的试验结果的基础上，即EEG α相干性和抽搐严重程度之间的负相关。此外，由于TS经常与ADHD（一种与反应抑制不良相关的疾病）同时发生，我们还将比较TS未与ADHD同时发生的儿童与TS和ADHD儿童。为了证实患有TS的儿童与没有ADHD的儿童之间的差异确实是由于ADHD，我们将包括一个没有抽搐的ADHD儿童对照组。因此，这是一项涉及四组受试者的横断面研究：20名TS儿童无ADHD，20名TS和ADHD并存的儿童，20名ADHD儿童无抽搐，20名匹配的健康社区对照。在这项横断面研究中，EEG α相干性作为抽搐和抽搐抑制的生物标志物的验证将为开发基于机制的TS治疗方法和计划纵向研究以绘制这种疾病的过程奠定基础。 公共卫生相关性：本研究的目的是检查TS中抽动严重程度和抽动抑制的生物标志物，TS是一种以运动和声音抽动为特征的儿童期神经精神疾病，影响了一般人群中约0.6%的儿童。抽动症生物标志物的发现和验证将促进对TS缓解与持续过程的理解，并促进机制驱动治疗的发展。