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In Vivo Dynamic Lumbar Vertebral Motion and Disc Deformation During Lifting Tasks

举重任务期间的体内动态腰椎运动和椎间盘变形

基本信息

批准号：
8328072
负责人：
XUDONG ZHANG
金额：
$ 18.92万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-01 至 2014-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8328072
关键词：
Vivo Dynamic Lumbar Vertebral Motion

项目摘要

DESCRIPTION (provided by applicant): Low back disorders (LBDs) remain one of most prevalent, debilitating, and costly occupational health problems in the United States. Mechanical loading on the lumbar spine is a central factor in the causation and prevention of occupational LBDs. The existing knowledge and methodological bases for evaluating mechanical forces on the lumbo-sacral (L5-S1) inter-vertebral disc were largely developed from static and/or in vitro cadaveric studies, or from in vivo dynamic studies that did not determine the internal vertebral movement or disc deformation. They are limited in their applicability in assessing the low back disorder or injury risks associated with dynamic work activities such as manual load lifting. Our overarching hypothesis is that more accurate understanding of the dynamic responses of lumbar spine during load-lifting will lead to more effective prevention and control of LBDs. The objective of this exploratory study is to characterize the relationships between dynamic responses of the lumbar spine and lifting dynamics defined by the load and lifting kinematics (i.e., dynamic postures), and begin to develop an improved model for evaluating the low back mechanical stress associated with manual tasks. The study will take advantage of a state-of-the-art dynamic radiographic system capable of measuring lumbar vertebral kinematics in vivo with unprecedented accuracy, and our extensive experience of studying the biomechanics of load lifting. We will pursue two specific aims: Aim 1 is to characterize the relationship between lumbar vertebral kinematics and dynamic lifting posture and the effect of load lifted on the relationship; we will acquire data of the lumbar vertebral kinematics using the dynamic X-ray system and the whole-body lifting kinematics using a motion capture system during the performance of lifting tasks. Aim 2 is to characterize the dynamic relationship between L5-S1 disc deformation and compressive force distribution; we will create a novel "spring-loaded wobbling platform" model to characterize this relationship and specify it empirically using data obtained from Aim 1; we will compare the L5-S1 disc compressive forces determined based on the new dynamic relationship and by the conventional approach which does not take into account the dynamic disc deformation. The proposed project is the first attempt to investigate the truly dynamic and in vivo mechanical behavior of the lumbar spine during lifting activities. It will pave the way for developing much improved capabilities to assess or predict low back mechanical stress during dynamic manual lifting. It will also afford a unique opportunity to establish new criteria (e.g., in vivo strain-based instead of stress-based) for disc tissue tolerance/failure. This work, along with a series of systematic studies that would naturally follow, will lead to a new body of knowledge and next-generation guidelines, models, and tools for better recognition, evaluation, and control of the risk of occupational low back disorders.

描述（由申请人提供）：腰部疾病 (LBD) 仍然是美国最普遍、最令人衰弱且代价高昂的职业健康问题之一。腰椎上的机械负荷是职业性腰椎病的病因和预防的核心因素。评估腰骶（L5-S1）椎间盘机械力的现有知识和方法基础主要来自静态和/或体外尸体研究，或来自无法确定内部椎体运动或椎间盘变形的体内动态研究。它们在评估与动态工作活动（例如手动举重）相关的腰部疾病或受伤风险方面的适用性有限。我们的总体假设是，更准确地了解腰椎在举重过程中的动态反应将有助于更有效地预防和控制小腰椎病。这项探索性研究的目的是表征腰椎的动态响应与由负载和举升运动学（即动态姿势）定义的举升动力学之间的关系，并开始开发一种改进的模型来评估与手动任务相关的腰背机械应力。该研究将利用最先进的动态放射线照相系统，能够以前所未有的精度测量体内腰椎运动学，以及我们在研究举重生物力学方面的丰富经验。我们将追求两个具体目标：目标1是表征腰椎运动学和动态举升姿势之间的关系以及举升负载对这种关系的影响；在执行提升任务时，我们将使用动态X射线系统获取腰椎运动学数据，并使用运动捕捉系统获取全身提升运动学数据。目标 2 是表征 L5-S1 椎间盘变形与压缩力分布之间的动态关系；我们将创建一个新颖的“弹簧加载摆动平台”模型来表征这种关系，并使用从目标 1 获得的数据根据经验指定它；我们将比较基于新的动态关系和不考虑动态椎间盘变形的传统方法确定的 L5-S1 椎间盘压缩力。该项目是研究举重活动期间腰椎真正动态和体内机械行为的首次尝试。它将为开发大幅改进的能力铺平道路，以评估或预测动态手动举重过程中的腰部机械应力。它还将为建立椎间盘组织耐受/失效的新标准（例如，基于体内应变而不是基于压力）提供独特的机会。这项工作以及随之而来的一系列系统研究将带来新的知识体系和下一代指南、模型和工具，以更好地识别、评估和控制职业性腰背疾病的风险。