Imaging neurotoxicity: The effect of anti-NMDAR Ab on hippocampus and amygdala in

影像神经毒性:抗 NMDAR 抗体对海马和杏仁核的影响

基本信息

项目摘要

Project 3: "Imaging neurotoxicity: The effect of anti-NMDAR Ab on hippocampus and amygdala in NPSLE patients" (Hirsch, PI) Systemic lupus erythematosus is an autoimmune disease characterized by the presence of anti-nuclear antibodies, especially antibodies to DNA. Patients with lupus develop, over time, cognitive impairment and mood disorders. We have identified a subset of anti-DNA antibodies that cross-reacts with the NR2A and NR2B subunits of the NMDA receptor (NMDAR). In mice, antibodies with this crossreactivity can cause apoptosis of neurons in the hippocampus or the amygdala, leading to cognitive impairment or behavioral dysfunction, respectively. We hypothesize that antibody, together with a breach in the blood-brain barrier, can damage the hippocampus and amygdala in lupus patients, and that insults that open the blood-brain barrier accumulate over time. This project is designed to assess whether functional Magnetic Resonance Imagining (fMRI) is a sensitive modality to assess cognitive function and emotional response in patients with SLE and whether the subset of anti-DNA antibodies that cross-reacts with the NMDAR associates with impairment. We will determine whether patients with anti-NMDAR antibodies acquire impairment over time using fMRI to assess activity in the hippocampus and the amygdala, regions subserving cognition and emotional memory. Two studies are proposed: a cohort analysis to determine whether antibody associates with impairment in patients with disease for 10 or more years, and whether antibody associates with early impairment in patients with disease for less than 2 years. The second study is a longitudinal assessment of patients to determine if fMRI can detect change over a 6 month time interval. This study is a necessary precondition to a clinical trial of neuroprotection in SLE.
项目3:“成像神经毒性:抗nmdar Ab对大鼠海马和杏仁核的影响”

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Joy Hirsch其他文献

Joy Hirsch的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Joy Hirsch', 18)}}的其他基金

Mechanisms of Dynamic Neural Coupling during Face-to-Face Expressions of Emotion
面对面情感表达过程中的动态神经耦合机制
  • 批准号:
    9883842
  • 财政年份:
    2019
  • 资助金额:
    $ 40.49万
  • 项目类别:
Mechanisms of Dynamic Neural Coupling during Face-to-Face Expressions of Emotion
面对面情感表达过程中的动态神经耦合机制
  • 批准号:
    10542713
  • 财政年份:
    2019
  • 资助金额:
    $ 40.49万
  • 项目类别:
Mechanisms of Dynamic Neural Coupling during Face-to-Face Expressions of Emotion
面对面情感表达过程中的动态神经耦合机制
  • 批准号:
    10319996
  • 财政年份:
    2019
  • 资助金额:
    $ 40.49万
  • 项目类别:
Mechanisms of Dynamic Neural Coupling during Face-to-Face Expressions of Emotion
面对面情感表达过程中的动态神经耦合机制
  • 批准号:
    10084718
  • 财政年份:
    2019
  • 资助金额:
    $ 40.49万
  • 项目类别:
Neural Mechanisms for Social Interactions and Eye Contact in ASD
自闭症谱系障碍 (ASD) 中社交互动和目光接触的神经机制
  • 批准号:
    9216715
  • 财政年份:
    2016
  • 资助金额:
    $ 40.49万
  • 项目类别:
Neural Mechanisms for Social Interactions and Eye Contact in ASD
自闭症谱系障碍 (ASD) 中社交互动和目光接触的神经机制
  • 批准号:
    9514249
  • 财政年份:
    2016
  • 资助金额:
    $ 40.49万
  • 项目类别:
Mechanisms of Interpersonal Social Communication: Dual-Brain fNIRS Investigation
人际社交沟通机制:双脑 fNIRS 研究
  • 批准号:
    9488538
  • 财政年份:
    2015
  • 资助金额:
    $ 40.49万
  • 项目类别:
Imaging neurotoxicity: The effect of anti-NMDAR Ab on hippocampus and amygdala in
影像神经毒性:抗 NMDAR 抗体对海马和杏仁核的影响
  • 批准号:
    8122315
  • 财政年份:
  • 资助金额:
    $ 40.49万
  • 项目类别:
Imaging neurotoxicity: The effect of anti-NMDAR Ab on hippocampus and amygdala in
影像神经毒性:抗 NMDAR 抗体对海马和杏仁核的影响
  • 批准号:
    8308306
  • 财政年份:
  • 资助金额:
    $ 40.49万
  • 项目类别:
Imaging neurotoxicity: The effect of anti-NMDAR Ab on hippocampus and amygdala in
影像神经毒性:抗 NMDAR 抗体对海马和杏仁核的影响
  • 批准号:
    7916745
  • 财政年份:
  • 资助金额:
    $ 40.49万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了