Imaging neurotoxicity: The effect of anti-NMDAR Ab on hippocampus and amygdala in
影像神经毒性:抗 NMDAR 抗体对海马和杏仁核的影响
基本信息
- 批准号:8380682
- 负责人:
- 金额:$ 40.49万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至 2014-06-30
- 项目状态:已结题
- 来源:
- 关键词:AgeAmygdaloid structureAnti-DNA AntibodiesAntibodiesAutoantibodiesAutoimmune DiseasesBehavioralBindingBlood - brain barrier anatomyBrainCardiolipinsCessation of lifeClinical TrialsCognitionCognitiveCohort AnalysisCohort StudiesCross-Sectional StudiesDNADiseaseEmotionalEmotionsFunctional Magnetic Resonance ImagingFunctional disorderGenderGlutamatesGoalsHippocampus (Brain)Hypertensive EpisodeImageImaging TechniquesImpaired cognitionImpairmentIndividualInfectionInstitutesLupusMagnetic ResonanceMeasurementMeasuresMediatingMedical ResearchMemoryMental DepressionMethodologyModalityMood DisordersMoodsMusN-Methyl-D-Aspartate ReceptorsNeuraxisNeurologicNeuronal DysfunctionNeuronsNuclearOnset of illnessOutcome MeasurePathogenesisPatientsPharmaceutical PreparationsPlayProcessResearch PersonnelRoleSerumSignal TransductionStressSystemic Lupus ErythematosusTestingTimeUniversitiescognitive changecognitive functioncohortconditioned feardesignexperiencefunctional disabilityillness lengthneuron apoptosisneuroprotectionneuropsychologicalneurotoxicitypreconditioningpreventrelating to nervous systemresponsesecondary outcometime intervaltime usetool
项目摘要
Project 3: "Imaging neurotoxicity: The effect of anti-NMDAR Ab on hippocampus and amygdala in
NPSLE patients" (Hirsch, PI)
Systemic lupus erythematosus is an autoimmune disease characterized by the presence of anti-nuclear
antibodies, especially antibodies to DNA. Patients with lupus develop, over time, cognitive impairment
and mood disorders. We have identified a subset of anti-DNA antibodies that cross-reacts with the
NR2A and NR2B subunits of the NMDA receptor (NMDAR). In mice, antibodies with this crossreactivity
can cause apoptosis of neurons in the hippocampus or the amygdala, leading to cognitive
impairment or behavioral dysfunction, respectively. We hypothesize that antibody, together with a
breach in the blood-brain barrier, can damage the hippocampus and amygdala in lupus patients, and that
insults that open the blood-brain barrier accumulate over time.
This project is designed to assess whether functional Magnetic Resonance Imagining (fMRI) is a
sensitive modality to assess cognitive function and emotional response in patients with SLE and whether
the subset of anti-DNA antibodies that cross-reacts with the NMDAR associates with impairment. We
will determine whether patients with anti-NMDAR antibodies acquire impairment over time using fMRI
to assess activity in the hippocampus and the amygdala, regions subserving cognition and emotional
memory. Two studies are proposed: a cohort analysis to determine whether antibody associates with
impairment in patients with disease for 10 or more years, and whether antibody associates with early
impairment in patients with disease for less than 2 years. The second study is a longitudinal assessment
of patients to determine if fMRI can detect change over a 6 month time interval. This study is a
necessary precondition to a clinical trial of neuroprotection in SLE.
项目3:“成像神经毒性:抗nmdar Ab对大鼠海马和杏仁核的影响”
项目成果
期刊论文数量(0)
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科研奖励数量(0)
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专利数量(0)
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Joy Hirsch其他文献
Joy Hirsch的其他文献
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{{ truncateString('Joy Hirsch', 18)}}的其他基金
Mechanisms of Dynamic Neural Coupling during Face-to-Face Expressions of Emotion
面对面情感表达过程中的动态神经耦合机制
- 批准号:
9883842 - 财政年份:2019
- 资助金额:
$ 40.49万 - 项目类别:
Mechanisms of Dynamic Neural Coupling during Face-to-Face Expressions of Emotion
面对面情感表达过程中的动态神经耦合机制
- 批准号:
10542713 - 财政年份:2019
- 资助金额:
$ 40.49万 - 项目类别:
Mechanisms of Dynamic Neural Coupling during Face-to-Face Expressions of Emotion
面对面情感表达过程中的动态神经耦合机制
- 批准号:
10319996 - 财政年份:2019
- 资助金额:
$ 40.49万 - 项目类别:
Mechanisms of Dynamic Neural Coupling during Face-to-Face Expressions of Emotion
面对面情感表达过程中的动态神经耦合机制
- 批准号:
10084718 - 财政年份:2019
- 资助金额:
$ 40.49万 - 项目类别:
Neural Mechanisms for Social Interactions and Eye Contact in ASD
自闭症谱系障碍 (ASD) 中社交互动和目光接触的神经机制
- 批准号:
9216715 - 财政年份:2016
- 资助金额:
$ 40.49万 - 项目类别:
Neural Mechanisms for Social Interactions and Eye Contact in ASD
自闭症谱系障碍 (ASD) 中社交互动和目光接触的神经机制
- 批准号:
9514249 - 财政年份:2016
- 资助金额:
$ 40.49万 - 项目类别:
Mechanisms of Interpersonal Social Communication: Dual-Brain fNIRS Investigation
人际社交沟通机制:双脑 fNIRS 研究
- 批准号:
9488538 - 财政年份:2015
- 资助金额:
$ 40.49万 - 项目类别:
Imaging neurotoxicity: The effect of anti-NMDAR Ab on hippocampus and amygdala in
影像神经毒性:抗 NMDAR 抗体对海马和杏仁核的影响
- 批准号:
8122315 - 财政年份:
- 资助金额:
$ 40.49万 - 项目类别:
Imaging neurotoxicity: The effect of anti-NMDAR Ab on hippocampus and amygdala in
影像神经毒性:抗 NMDAR 抗体对海马和杏仁核的影响
- 批准号:
8308306 - 财政年份:
- 资助金额:
$ 40.49万 - 项目类别:
Imaging neurotoxicity: The effect of anti-NMDAR Ab on hippocampus and amygdala in
影像神经毒性:抗 NMDAR 抗体对海马和杏仁核的影响
- 批准号:
7916745 - 财政年份:
- 资助金额:
$ 40.49万 - 项目类别: