STRUCTURAL CHARACTERIZATION OF THE TYPE 3 SECRETION SYSTEM

3 型分泌系统的结构特征

• 批准号: 8361578
• 负责人: Charles Erec Stebbins
• 金额: $ 0.39万
• 依托单位: ROCKEFELLER UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361578
• 关键词: Funding; Grant; Injection of therapeutic agent; Mass Spectrum Analysis; Membrane; National Center for Research Resources; Principal Investigator; Research; Research Infrastructure; Resources; Salmonella; Source; System; United States National Institutes of Health; Virulence Factors; cost; macromolecule; pathogen; protein complex; stoichiometry

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We are planning to use native mass spectrometry to determine the subunit stoichiometry of a very large (>2MDa) membrane spanning protein complex - the Type 3 Secretion System. The Type 3 Secretion System is involved in injection of virulence factors by pathogen such as salmonella.

这个子项目是利用这些资源的众多研究子项目之一