PROTEOMIC ANALYSIS OF HUMAN CEREBROSPINAL FLUID

人类脑脊液的蛋白质组分析

• 批准号: 8361371
• 负责人: DAVID HOLTZMAN
• 金额: $ 1.82万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361371
• 关键词: Alzheimer' s Disease; Biological Markers; Central Nervous System Diseases; Cerebrospinal Fluid; Disease; Funding; Grant; Human; Individual; Mass Spectrum Analysis; National Center for Research Resources; Pattern; Principal Investigator; Proteins; Proteomics; Research; Research Infrastructure; Resources; Sampling; Source; Time; United States National Institutes of Health; Variant; biomedical resource; cost

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Cerebrospinal fluid (CSF) is a potential source of biomarkers for many disorders of the central nervous system, including Alzheimer disease (AD). Prior to comparing CSF samples between individuals to identify patterns of disease-associated proteins, it is important to examine variation within individuals over a short period of time so that one can better interpret potential changes in CSF between individuals as well as changes within a given individual over a longer time span.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 脑脊液（CSF）是包括阿尔茨海默病（AD）在内的许多中枢神经系统疾病的生物标志物的潜在来源。在比较个体之间的CSF样本以识别疾病相关蛋白的模式之前，重要的是在短时间内检查个体内的变化，以便可以更好地解释个体之间CSF的潜在变化以及给定个体内的变化。