SAFETY OF MESENCHYMAL STEM CELL ADMINISTRATION TO THE CNS OF RHESUS MACAQUES

间充质干细胞对恒河猴中枢神经系统给药的安全性

• 批准号: 7958350
• 负责人: Donald G Phinney
• 金额: $ 6.49万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958350
• 关键词: Affect; Anatomy; Animals; Behavior; Behavioral; Bone Marrow; Brain; Computer Retrieval of Information on Scientific Projects Database; Disease; Engraftment; Funding; Goals; Grant; Institution; Macaca mulatta; Mesenchymal Stem Cells; Motor; Neurologic; New England; Performance; Primates; Research; Research Personnel; Resources; Safety; Source; Stem cell transplant; United States National Institutes of Health; base; nonhuman primate; performance tests; vector

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of this project is to evaluate in non-human primates the safety and potential efficacy of bone marrow-derived mesenchymal stem cells (MSCs) as cellular vectors for treating neurologic diseases. Specifically, MSCs are transplanted directly into the CNS and their overall engraftment and anatomic distribution in brain is evaluated. Prior to and after MSC administration animals are subjected to a battery of behavioral and motor performance tests. Correlating MSC engraftment with affects on behavior and motor performance provides a means to evaluate the safety and overall utility of MSCs for treating neurologic diseases.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该项目的总体目标是在非人类灵长类动物中评估骨髓间充质干细胞（MSC）作为治疗神经系统疾病的细胞载体的安全性和潜在功效。 具体来说，间充质干细胞被直接移植到中枢神经系统中，并评估它们在大脑中的整体植入和解剖分布。 在 MSC 给药之前和之后，动物要接受一系列行为和运动表现测试。 将 MSC 植入与对行为和运动表现的影响联系起来，提供了一种评估 MSC 治疗神经系统疾病的安全性和整体效用的方法。