SAFETY OF MESENCHYMAL STEM CELL ADMINISTRATION TO THE CNS OF RHESUS MACAQUES

间充质干细胞对恒河猴中枢神经系统给药的安全性

• 批准号: 7958350
• 负责人: Donald G Phinney
• 金额: $ 6.49万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958350
• 关键词: Affect; Anatomy; Animals; Behavior; Behavioral; Bone Marrow; Brain; Computer Retrieval of Information on Scientific Projects Database; Disease; Engraftment; Funding; Goals; Grant; Institution; Macaca mulatta; Mesenchymal Stem Cells; Motor; Neurologic; New England; Performance; Primates; Research; Research Personnel; Resources; Safety; Source; Stem cell transplant; United States National Institutes of Health; base; nonhuman primate; performance tests; vector

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of this project is to evaluate in non-human primates the safety and potential efficacy of bone marrow-derived mesenchymal stem cells (MSCs) as cellular vectors for treating neurologic diseases. Specifically, MSCs are transplanted directly into the CNS and their overall engraftment and anatomic distribution in brain is evaluated. Prior to and after MSC administration animals are subjected to a battery of behavioral and motor performance tests. Correlating MSC engraftment with affects on behavior and motor performance provides a means to evaluate the safety and overall utility of MSCs for treating neurologic diseases.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该项目的总体目标是在非人类灵长类动物中评估骨髓间充质干细胞(MSCs)作为细胞载体用于治疗神经系统疾病的安全性和潜在有效性。具体地说，将MSCs直接移植到中枢神经系统，并对其整体植入和在脑内的解剖分布进行评估。在注射MSC前后，动物都要接受一系列的行为和运动能力测试。将骨髓间充质干细胞移植与对行为和运动能力的影响相关联，为评估骨髓间充质干细胞治疗神经系统疾病的安全性和整体有效性提供了一种手段。