Molecular Regulation of the Serine-Threonine Kinase ULK1 in Autophagy

自噬中丝氨酸-苏氨酸激酶 ULK1 的分子调控

• 批准号: nhmrc : 596849
• 负责人: Dr Georg Ramm
• 金额: $ 19.97万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-regulation-serine-ulk1-autophagy/95351
• 关键词: Molecular; Regulation; Serine; Threonine; Kinase

Autophagy or self eating is a basic cellular process and can have either beneficial or adverse effects in cancer. It is essential to determine the status of autophagy in patients before considering drugs that block autophagy for therapy. A protein called ULK1 is needed for autophagy and may emerge as a pathological marker for autophagy in cancer as well as a potential drug target. This grant proposal will study ULK1 regulation and will lay the scientific foundation for its medical application.

自噬或自食是一种基本的细胞过程，对癌症可能产生有益或不利的影响。在考虑使用阻断自噬的药物进行治疗之前，必须确定患者自噬的状态。自噬需要一种名为 ULK1 的蛋白质，它可能成为癌症自噬的病理标志物以及潜在的药物靶点。该资助提案将研究ULK1调控并为其医学应用奠定科学基础。