Molecular regulation of Tim3 signalling in T cells

T 细胞中 Tim3 信号传导的分子调控

• 批准号: nhmrc : 1111469
• 金额: $ 22.89万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-regulation-tim3-t-cells/663180
• 关键词: Molecular; regulation; Tim3; signalling; cells

Chronic inflammatory diseases like multiple sclerosis and cancer can be rectified via interventions of T cell checkpoint pathway. Tim3 is a T cell checkpoint molecule that is gaining extreme interest in these diseases. Here, we aim to identify molecular mechanism(s) to suppress or enhance Tim3 signalling in effector T cell, potentially leading to the development of therapeutic intervention to treat autoimmune disorders and cancers.

慢性炎症性疾病如多发性硬化症和癌症可以通过T细胞检查点途径的干预来纠正。Tim3是一种T细胞检查点分子，在这些疾病中引起了极大的兴趣。在这里，我们的目标是确定抑制或增强效应T细胞中Tim3信号传导的分子机制，可能导致治疗自身免疫性疾病和癌症的治疗干预的发展。