Chemoprevention of lung cancer with red ginseng extracts

红参提取物对肺癌的化学预防

基本信息

  • 批准号:
    8133545
  • 负责人:
  • 金额:
    $ 46.21万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2009
  • 资助国家:
    美国
  • 起止时间:
    2009-09-30 至 2013-08-31
  • 项目状态:
    已结题

项目摘要

* DESCRIPTION (provided by applicant): The overall objective of this proposal is to characterize red ginseng extract (RGE) and its key active components (KAC) preclinically as a potent lung cancer chemopreventive agent. In a preliminary study, we demonstrated a strong efficacy of red ginseng in chemoprevention against lung tumor development in A/J mice. We hypothesize that ginseng will prevent chemically induced lung adenocarcinoma and squamous cell carcinoma formation in a mutant mouse model with genetic changes commonly seen in human lung cancers. Four specific aims are proposed to test this hypothesis. Aim 1 will identify the key active components of red ginseng via in vitro activity- guided fractionation chromatographic separation supplemented by measuring their intestinal absorption potentials. Aim 2 will evaluate the effect of RGE and its KAC on lung adenocarcinoma carcinogenesis in a transgenic mouse lung adenocarcinoma model with genetic changes commonly seen in human lung cancers. Aim 3 will determine the effect of RGE and its KAC on lung squamous cell carcinoma development in p53 mutant mice. Aim 4 will perform pharmacokinetic and biopharmaceutical characterizations of RGE and its KAC. This proposal is timely and significant since future chemoprevention clinical trials of ginseng against lung cancer in humans require vigorous preclinical characterization of its efficacy and biopharmaceutical characteristics such as bioavailability and pharmacokinetic profile. Furthermore, we will use a newly developed mutant mouse lung tumor models of both lung adenocarcinoma and lung squamous cell carcinoma, which shares both histopathological features and genetic alterations observed in human lung carcinogenesis. The results from this proposal will provide a solid foundation for clinical trials of ginseng as a lung cancer chemopreventive agent. PUBLIC HEALTH RELEVANCE: PROJECT NARRATIVE We propose to characterize red ginseng extracts (RGE) preclinically as a potent lung cancer chemopreventive agent. In vitro experiments have shown that ginseng inhibits cell proliferation and induces apoptosis in tumor cell lines. In vivo, ginseng has been shown to inhibit rodent carcinogenesis in various organ sites including the lung. We will identify the key active components of red ginseng via in vitro activity-guided fractionation chromatographic separation supplemented by measuring their intestinal absorption potentials, evaluate the effect of ginseng on lung carcinogenesis in a transgenic mouse lung carcinoma model with genetic changes commonly seen in human lung cancers, and perform pharmacokinetic and biopharmaceutical characterizations of red ginseng and its key active components. We believe that the proposed studies are significant because future chemoprevention clinical trials of ginseng against lung cancer in humans require vigorous preclinical characterization of its efficacy and biopharmaceutical characteristics such as bioavailability and pharmacokinetic profile.

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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MING YOU其他文献

MING YOU的其他文献

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{{ truncateString('MING YOU', 18)}}的其他基金

IGF::OT::IGF LUNG CANCER CHEMOPREVENTION BY MICRORNA DELIVERY
通过 MICRORNA 递送进行 IGF::OT::IGF 肺癌化学预防
  • 批准号:
    9356882
  • 财政年份:
    2016
  • 资助金额:
    $ 46.21万
  • 项目类别:
TARGETED, LABEL-FREE PROTEOMIC ANALYSIS OF URINE IN A RAT BLADDER CANCER MODEL
对大鼠膀胱癌模型中的尿液进行有针对性的、无标记的蛋白质组学分析
  • 批准号:
    8361368
  • 财政年份:
    2011
  • 资助金额:
    $ 46.21万
  • 项目类别:
TARGETED, LABEL-FREE PROTEOMIC ANALYSIS OF URINE IN A RAT BLADDER CANCER MODEL
对大鼠膀胱癌模型中的尿液进行有针对性的、无标记的蛋白质组学分析
  • 批准号:
    8168722
  • 财政年份:
    2010
  • 资助金额:
    $ 46.21万
  • 项目类别:
Chemoprevention of lung cancer with red ginseng extracts
红参提取物对肺癌的化学预防
  • 批准号:
    8324234
  • 财政年份:
    2009
  • 资助金额:
    $ 46.21万
  • 项目类别:
TARGETED, LABEL-FREE PROTEOMIC ANALYSIS OF URINE IN A RAT BLADDER CANCER MODEL
对大鼠膀胱癌模型中的尿液进行有针对性的、无标记的蛋白质组学分析
  • 批准号:
    7953950
  • 财政年份:
    2009
  • 资助金额:
    $ 46.21万
  • 项目类别:
Chemoprevention of lung cancer with red ginseng extracts
红参提取物对肺癌的化学预防
  • 批准号:
    7936365
  • 财政年份:
    2009
  • 资助金额:
    $ 46.21万
  • 项目类别:
Chemoprevention of lung cancer with red ginseng extracts
红参提取物对肺癌的化学预防
  • 批准号:
    7777978
  • 财政年份:
    2009
  • 资助金额:
    $ 46.21万
  • 项目类别:
Molecular Characterization of Stage I Lung Cancer
I 期肺癌的分子特征
  • 批准号:
    7790523
  • 财政年份:
    2008
  • 资助金额:
    $ 46.21万
  • 项目类别:
Molecular Characterization of Stage I Lung Cancer
I 期肺癌的分子特征
  • 批准号:
    7466801
  • 财政年份:
    2008
  • 资助金额:
    $ 46.21万
  • 项目类别:
Molecular Characterization of Stage I Lung Cancer
I 期肺癌的分子特征
  • 批准号:
    7640610
  • 财政年份:
    2008
  • 资助金额:
    $ 46.21万
  • 项目类别:

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